文献类型：期刊文献

英文题名：A Supramolecular Crosslinker To Give Salt-Resistant Polyion Complex Micelles and Improved MRI Contrast Agents

作者：Wang, Jiahua[1,2];Wang, Junyou[1,2];Ding, Peng[1,2];Zhou, Wenjuan[1,2];Li, Yuehua[3];Drechsler, Markus[4];Guo, Xuhong[1,2];Stuart, Martien A. Cohen[1,2]

机构：[1]East China Univ Sci & Technol, State Key Lab Chem Engn, 130 Meilong Rd, Shanghai 200237, Peoples R China;[2]East China Univ Sci & Technol, Shanghai Key Lab Multiphase Mat Chem Engn, 130 Meilong Rd, Shanghai 200237, Peoples R China;[3]Shanghai Jiao Tong Univ, Affiliated Peoples Hosp 6, Inst Diagnost & Intervent Radiol, 600 Yi Shan Rd, Shanghai 200233, Peoples R China;[4]Univ Bayreuth, Key Lab Electron & Opt Microscopy, BPI, Univ Str 30, D-95440 Bayreuth, Germany

年份：2018

卷号：57

期号：39

起止页码：12680

外文期刊名：ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

收录：;EI(收录号：20183605789536);WOS:【SCI-EXPANDED(收录号:WOS:000444941600009)】；

基金：This work was financially supported by the Shanghai Municipal Natural Science Foundation (17ZR1440500, 17PJ1401800).

语种：英文

外文关键词：coordination polymers; MRI contrast agents; polyelectrolytes micelles; tunable stability and properties

摘要：Three-component mixtures (diblock copolymer/metal ion/oligoligand) can assemble into micellar particles owing to a combination of supramolecular polymerization and electrostatic complex formation. Such particles cover a large range of compositions, but the electrostatic forces keeping them together make them rather susceptible to disintegration by added salt. Now it is shown how the salt stability can be tuned continuously by employing both a bis-ligand and a tris-ligand, and varying the ratio of these in the mixture. For magnetic ions such as Mn-II and Fe-III, the choice of the multiligand also affects the ion/water interaction and, hence, the magnetic relaxivity. As an example, Mn-II-based nanoparticles with a very high longitudinal relaxivity (10.8 mm(-1) s(-1)) were investigated that are not only biocompatible but also feature strong contrast enhancement in target organs (liver, kidney), as shown by T-1-weighted invivo magnetic resonance imaging (MRI).