文献类型：期刊文献

英文题名：Antibacterial Functions and Proposed Modes of Action of Novel 1,2,3,4-Tetrahydro-β-carboline Derivatives that Possess an Attractive 1,3-Diaminopropan-2-ol Pattern against Rice Bacterial Blight, Kiwifruit Bacterial Canker, and Citrus Bacterial Canker

作者：Liu, Hong-Wu[1];Ji, Qing-Tian[1];Ren, Gang-Gang[1];Wang, Fang[1];Su, Fen[1];Wang, Pei-Yi[1];Zhou, Xiang[1];Wu, Zhi-Bing[1];Li, Zhong[2];Yang, Song[1,2]

机构：[1]Guizhou Univ, Ctr R&D Fine Chem, Key Lab Green Pesticide & Agr Bioengn,Minist Educ, State Key Lab Breeding Base Green Pesticide & Agr, Guiyang 550025, Peoples R China;[2]East China Univ Sci & Technol, Coll Pharm, Shanghai 200237, Peoples R China

年份：2020

卷号：68

期号：45

起止页码：12558

外文期刊名：JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY

收录：;EI(收录号：20204909564261);WOS:【SCI-EXPANDED(收录号:WOS:000592487700005)】；

基金：We acknowledge funds from the National Natural Science Foundation of China (21662009, 21702037, 21877021, 31860516), the Research Project of Ministry of Education (20135201110005, 213033A), the Guizhou Provincial S&T Program (LH [2017]7259, [2017]5788), and the Key Technologies R&D Program (2014BAD23B01).

语种：英文

外文关键词：tetrahydro-beta-carboline derivatives; antiphytopathogen; in vitro and in vivo bioassays; ROS; apoptosis; hypersensitive response

摘要：In recent years, naturally occurring tetrahydro-/3-carboline (THC) alkaloids and their derivatives have been of biological interest. However, few studies and developments have reported the use of such structures in managing plant bacterial diseases. Herein, an array of novel THC derivatives containing an attractive 1,3-diaminopropan-2-ol pattern were prepared to evaluate the antiphytopathogen activity in vitro and in vivo and explore innovative antibacterial frameworks. Notably, target compounds exhibited excellent activities against three rebellious phytopathogens, namely, Pseudomonas syringae pv. actinidiae (Psa), Xanthomonas axonopodis pv. citri, and Xanthomonas oryzae pv. oryzae, at related optimal EC50 values of 2.39 (II9), 2.06 (I-23), and 1.69 (II9) mu g/mL, respectively. These effects were superior to those of the parent structure 1,2,3,4-THC and positive controls. In vivo assays showed that II9 exhibited excellent control efficiencies of 51.89 and 65.45% at 200 mu g/mL against rice bacterial blight and kiwifruit bacterial canker, respectively, and I-23 substantially relieved the citrus canker on the leaves. Antibacterial mechanisms indicated that these THC compounds could induce the increment of reactive oxygen species and subsequently endow the tested bacteria with distinct apoptotic behavior. In addition, II9 could alleviate the hypersensitive response and pathogenicity of Psa. Overall, these simple THC derivatives can be further developed as versatile antibacterial agents.