文献类型：期刊文献

英文题名：Palladium-Catalyzed Csp3-H Bond mono-Aroyloxylation of O-Alkyl Substituted 2,4,6-Trimethoxybenzaldoxime Ethers

作者：Qiao, Wen-Li[1];Shao, Ling-Yan[1];Hu, Ya-Hua[1];Xing, Li-Hao[1];Deng, Ke-Zuan[1];Liu, Hong-Wei[1];Liao, Dao-Hua[1];Ji, Ya-Fei[1]

机构：[1]East China Univ Sci & Technol, Sch Pharm, 130 Meilong Rd, Shanghai 200237, Peoples R China

年份：2018

卷号：29

期号：9

起止页码：1249

外文期刊名：SYNLETT

收录：;WOS:【SCI-EXPANDED(收录号:WOS:000432738600025)，CCR-EXPANDED(收录号:WOS:000432738600025)】；

基金：We gratefully thank the National Natural Science Foundation of China (Project Nos. 21476074 and 21676088) for financial support.

语种：英文

外文关键词：palladium-catalysis; Csp(3)-H bond functionalization; aroyloxylation; masked aliphatic alcohol; oxidative cross-coupling

摘要：A palladium-catalyzed Csp(3)-H bond mono-aroyloxylation of O-alkyl substituted oxime ethers has been developed by using 2,4,6-trimethoxybenzaldoxime as an exo-type directing group with exclusive site-selectivity. With the wide range of masked aliphatic alcohol substrates and aromatic acid coupling partners, the protocol allows rapid access to various 2-alkyl substituted glycol derivatives in synthetically useful to good yields. The employed directing group is readily removed, accordingly affording valuable functionalized aliphatic alcohols. When the solvent from hybrid DCE/HFIP to CH3CN, non-directed oxidative cross-coupling is observed between the electron-rich aromatic ring of substrates and aromatic acid partners.