文献类型：期刊文献

英文题名：Exploring the effect of PVP on the spherical agglomeration process and micromeritic properties of ascorbic acid

作者：Huang, Saixu[1];Liu, Yan[1];Zhou, Yaru[1];Li, Qiang[1];Ren, Guobin[1];Jing, Qiufang[1,2];Ren, Fuzheng[1,2]

机构：[1]East China Univ Sci & Technol, Sch Pharm, Lab Pharmaceut Crystal Engn & Technol, Shanghai 200237, Peoples R China;[2]East China Univ Sci & Technol, Sch Pharm, Shanghai Key Lab New Drug Design, Shanghai 200237, Peoples R China

年份：2019

卷号：342

起止页码：929

外文期刊名：POWDER TECHNOLOGY

收录：;EI(收录号：20184506051617);WOS:【SCI-EXPANDED(收录号:WOS:000454375100092)】；

基金：The authors are grateful for support from the Shanghai Committee of Science and Technology (grant no. 14DZ1930802) and the National Natural Science Foundation of China (grant no. 21576080).

语种：英文

外文关键词：Fourier transform infrared spectroscopy - Spheres - Hydrogen bonds - Nuclear magnetic resonance spectroscopy - Differential scanning calorimetry

摘要：Spherical agglomerated crystals of ascorbic acid (AA) have been prepared with a trace of polyvinylpyrrolidone (PVP) by a spherical agglomeration method. The process of spherical crystallization has been monitored online with a partide vision and measurement (PVM) probe. The effect of PVP on the metastable zone width of ascorbic acid in aqueous solutions has been characterized by a laser method. Hydrogen bonding interactions between AA and PVP have been identified by Fourier-transform infrared spectroscopy and H-1 nuclear magnetic resonance. Differential scanning calorimetry and powder X-ray diffraction measurements have shown that the prepared spherical crystals still exhibited a crystallin nature. The micromeritic properties, namely flowability, packability, and compressibility, were significantly improved compared to those of the pure drug crystals. In this study, we have explored the mechanism of the spherical crystallization process in the presence of the polymer, and the beneficial effect of the polymer on the micromeritic properties of crystals of ascorbic acid. (C) 2018 Elsevier B.V. All rights reserved.