文献类型：期刊文献

中文题名：丹参酮固体分散物的稳定性

英文题名：Stability of Solid Dispersion of Tanshinone

作者：储茂泉[1];古宏晨[2];刘国杰[1]

机构：[1]华东理工大学化学与制药学院,上海200237;[2]超细材料制备与应用教育部重点实验室,上海200237

年份：2002

卷号：28

期号：1

起止页码：107

中文期刊名：华东理工大学学报（自然科学版）

外文期刊名：Journal of East China University of Science and Technology

收录：CSTPCD;;Scopus;北大核心:【北大核心2000】；CSCD:【CSCD2011_2012】；

语种：中文

中文关键词：丹参酮;聚乙烯吡咯烷酮;喷雾干燥;固体分散;光稳定性;热稳定性;溶出度

外文关键词：tanshinone; poly(vinylpyrrolidone);spray drying;solid dispersion; stability

摘要：考察了丹参酮 ( tanshinone,TAN) -聚乙烯吡咯烷酮 ( PVP)的固体分散物在不同贮存环境中的稳定性以及对光和热的稳定性。结果表明 ,固体分散物于常温和干燥的环境中避光密闭贮存1年 ,其中的 TAN溶出度基本保持不变 ,而在 40°C和相对湿度为 75 %的环境中放置 3个月 ,有TAN晶体析出 ,溶出度有所降低。此外 ,加入 PVP可明显提高
The effect of different storing environment, light and heat on the stability of tanshinone (TAN) was investigated. Results show that the dissolution of TAN from the solid dispersion is about the same after being stored under the dry condition and room temperature for one year sheltered from light. However, when the solid dispersion was exposed to an atmosphere of 75% relative humidity (RH) for 3 months at 40°C , some crystalline of TAN appeared again, and the dissolution of TAN from the solid dispersion obviously decreased. In addition, the stability of TAN towards light and heat could be obviously improved by solid dispersion technique.