文献类型：期刊文献

英文题名：Peptide-Mimicking Poly(2-oxazoline)s Displaying Potent Antimicrobial Properties

作者：Zhou, Min[1];Jiang, Weinan[2];Xie, Jiayang[2];Zhang, Wenjing[1];Ji, Zhemin[2];Zou, Jingcheng[2];Cong, Zihao[2];Xiao, Ximian[2];Gu, Jiawei[2];Liu, Runhui[1,2]

机构：[1]East China Univ Sci & Technol, State Key Lab Bioreactor Engn, Shanghai 200237, Peoples R China;[2]East China Univ Sci & Technol, Key Lab Specially Funct Polymer Mat & Related Tec, Frontiers Sci Ctr Mat & Dynam Chem, Minist Educ,Sch Mat Sci & Engn, Shanghai 200237, Peoples R China

年份：2021

卷号：16

期号：2

起止页码：309

外文期刊名：CHEMMEDCHEM

收录：;WOS:【SCI-EXPANDED(收录号:WOS:000585070900001)】；

基金：This research was supported by the Natural Science Foundation of Shanghai (18ZR1410300), the National Natural Science Foundation of China (No. 21861162010, 21774031), the National Key Research and Development Program of China (2016YFC1100401), Research program of State Key Laboratory of Bioreactor Engineering, the Fundamental Research Funds for the Central Universities (No. 22221818014, 50321041917001, 222201814001). The authors thank Research Center of Analysis and Test of East China University of Science and Technology for the help on the characterization. The authors also thank the staff members of the Mass Spectrometry System at the National Facility for Protein Science (NFPS) for providing technical support and assistance in data collection and analysis.

语种：英文

外文关键词：poly(2-oxazoline); peptide mimicking; host defense peptide; antimicrobial resistance; antibacterial mechanism

摘要：Poly(2-oxazoline)s have excellent biocompatibility and have been used as FDA-approved indirect food additives. The inert property of the hydrophilic poly(2-oxazoline)s suggests them as promising substitutes for poly(ethylene glycol) (PEG) in various applications such as anti-biofouling agents. It was recently reported that poly(2-oxazoline)s themselves have antimicrobial properties as synthetic mimics of host defense peptides. These studies revealed the bioactive properties of poly(2-oxazoline)s as a new class of functional peptide mimics, by mimicking host defense peptides to display potent and selective antimicrobial activities against methicillin-resistant Staphylococcus aureus both in vitro and in vivo, without concerns about antimicrobial resistance. The high structural diversity, facile synthesis, and potent and tunable antimicrobial properties underscore the great potential of poly(2-oxazoline)s as a class of novel antimicrobial agents in dealing with drug-resistant microbial infections and antimicrobial resistance.