文献类型：期刊文献

英文题名：Selective homocysteine turn-on fluorescent probes and their bioimaging applications

作者：Lee, Hye Yeon[1];Choi, Yoon Pyo[2];Kim, Sunkyung[3];Yoon, Taejin[2];Guo, Zhiqian[1,4,5];Lee, Songyi[1];Swamy, K. M. K.[1,6];Kim, Gyoungmi[1];Lee, Jin Yong[3];Shin, Injae[2];Yoon, Juyoung[1]

机构：[1]Ewha Womans Univ, Dept Chem & Nano Sci, Seoul 120750, South Korea;[2]Yonsei Univ, Dept Chem, Seoul 120749, South Korea;[3]Sungkyunkwan Univ, Dept Chem, Suwon 440746, South Korea;[4]E China Univ Sci & Technol, Key Lab Adv Mat, Shanghai 200237, Peoples R China;[5]E China Univ Sci & Technol, Inst Fine Chem, Shanghai 200237, Peoples R China;[6]VL Coll Pharm, Dept Pharmaceut Chem, Raichur 584103, India

年份：2014

卷号：50

期号：53

起止页码：6967

外文期刊名：CHEMICAL COMMUNICATIONS

收录：;WOS:【SCI-EXPANDED(收录号:WOS:000337101800002)】；

基金：This study was supported by the National Research Foundation of Korea (NRF) grant (CRI No. 2012R1A3A2048814 for J.Y. and CRI No. 2010-0018272 for I.S.). The work at the Sungkyunkwan University was supported by the NRF grant (2007-0056343) funded by MEST.

语种：英文

摘要：The design and development of new pyrene-based fluorescent probes, P-Hcy-1 and P-Hcy-2, which display selective fluorescence enhancements in response to homocysteine (Hcy), are described. The distinctly different fluorescence responses of P-Hcy-1 and P-Hcy-2 to Hcy vs. Cys are explained by theoretical calculations. Finally, the results of cell experiments show that these probes can be used to selectively detect Hcy in mammalian cells.