文献类型：期刊文献

英文题名：Temperature-Dependent Cinchona Alkaloid Squaramide-Catalyzed Asymmetric Formal [3+2] Cycloaddition of Isocyanoacetates with -Trifluoromethylated Enones

作者：Zhao, Mei-Xin[1,2];Zhu, Guang-Yu[1,2];Zhu, Hui-Kai[1,2];Zhao, Xiao-Li[3];Ji, Ming[1,2];Shi, Min[1,2,4]

机构：[1]East China Univ Sci & Technol, Key Lab Adv Mat, 130 Mei Long Rd, Shanghai 200237, Peoples R China;[2]East China Univ Sci & Technol, Inst Fine Chem, 130 Mei Long Rd, Shanghai 200237, Peoples R China;[3]East China Normal Univ, Dept Chem, 3663 N Zhongshan Rd, Shanghai 200062, Peoples R China;[4]Chinese Acad Sci, Shanghai Inst Organ Chem, State Key Lab Organometall Chem, 354 Fenglin Rd, Shanghai 200032, Peoples R China

年份：2018

卷号：2018

期号：29

起止页码：3997

外文期刊名：EUROPEAN JOURNAL OF ORGANIC CHEMISTRY

收录：;WOS:【SCI-EXPANDED(收录号:WOS:000440920000016)，CCR-EXPANDED(收录号:WOS:000440920000016)】；

基金：We are grateful for financial support from the National Natural Science Foundation of China (21272067), the Natural Science Foundation of Shanghai (15ZR1411900) and the Fundamental Research Funds for the Central Universities (222201717003).

语种：英文

外文关键词：Organocatalysis; Cycloaddition; Isocyanoacetates; Enones; Pyrroles

摘要：An efficient temperature-dependent organocatalyzed asymmetric formal [3+2] cycloaddition reaction of -substituted isocyanoacetates to -trifluoromethylated enones by cinchona alkaloid-derived squaramide has been investigated, affording the optically active trifluoromethylated 2-pyrrolines in excellent yields (up to 98%) and high stereoselectivities (>20:1 dr, up to >99% ee) under mild conditions.