文献类型：期刊文献

英文题名：Construction of Spirocyclic Oxindoles through Regio- and Stereoselective [3+2] or [3+2]/[4+2] Cascade Reaction of ,-Unsaturated Imines with 3-Isothiocyanato Oxindole

作者：Du, Dan[1,2];Xu, Qin[1,2];Li, Xiao-Ge[3];Shi, Min[1,2,3]

机构：[1]E China Univ Sci & Technol, Key Lab Adv Mat, Meilong Rd 130, Shanghai 200237, Peoples R China;[2]E China Univ Sci & Technol, Inst Fine Chem, Meilong Rd 130, Shanghai 200237, Peoples R China;[3]Chinese Acad Sci, Shanghai Inst Organ Chem, State Key Lab Organometall Chem, 345 Lingling Rd, Shanghai 200032, Peoples R China

年份：2016

卷号：22

期号：14

起止页码：4733

外文期刊名：CHEMISTRY-A EUROPEAN JOURNAL

收录：;EI(收录号：20160902036071);WOS:【SCI-EXPANDED(收录号:WOS:000373163100013)】；

基金：We are grateful for the financial support from the National Basic Research Program of China (973)-2015CB856603, and the National Natural Science Foundation of China (20472096, 21372241, 21361140350, 20672127, 21421091, 21372250, 21121062, 21302203, 20732008, and 21572052).

语种：英文

外文关键词：asymmetric synthesis; cascade reaction; diastereoselectivity; organocatalysis; spirooxindole

摘要：On the basis of asymmetric regioselective [3+2] or [3+2]/[4+2] cascade reaction of 3-isothiocyanato oxindoles with C=C and C=N bonds of ,-unsaturated methanesulfonamides, diversified S-containing heterocyclic spirooxindole derivatives could be obtained in high yields along with good to excellent diastereo- and enantioselectivities under mild conditions in the presence of cinchona alkaloid-derived organocatalysts.