文献类型：期刊文献

英文题名：Additive-assisted synthesis of α-Kdo glycosides with peracetylated glycosyl ynenoate as a donor

作者：Miao, He[1];Lu, Siqian[1];Chen, Hongyu[1];Shang, Jintao[1];Zheng, Jibin[1];Yang, You[1]

机构：[1]East China Univ Sci & Technol, Shanghai Frontiers Sci Ctr Optogenet Tech Cell Met, Engn Res Ctr Pharmaceut Proc Chem,Shanghai Key Lab, Sch Pharm, 130 Meilong Rd, Shanghai 200237, Peoples R China

年份：2024

卷号：22

期号：12

起止页码：2365

外文期刊名：ORGANIC & BIOMOLECULAR CHEMISTRY

收录：;EI(收录号：20241015691329);WOS:【SCI-EXPANDED(收录号:WOS:001174490800001)，CCR-EXPANDED(收录号:WOS:001174490800001)】；

基金：Financial support from the National Natural Science Foundation of China (22071054, 21871081), and the Shanghai Frontiers Science Center of Optogenetic Techniques for Cell Metabolism (Shanghai Municipal Education Commission) is gratefully acknowledged.

语种：英文

外文关键词：Sugars

摘要：A DMF-modulated glycosylation approach for the stereoselective synthesis of alpha-Kdo glycosides with readily accessible peracetylated Kdo ynenoate as a donor was described. By utilizing this approach, we completed the synthesis of various linkage types of Kdo-Kdo disaccharides and the alpha-Kdo-containing protected trisaccharide variant relevant to the lipopolysaccharide of Coxiella burnetii strain Nine Mile. Additive-assisted alpha-selective Kdo glycosylation using a peracetylated Kdo ynenoate is described for stereoselective synthesis of the protected trisaccharide variant relevant to the lipopolysaccharide of Coxiella burnetii strain Nine Mile.