文献类型：期刊文献

英文题名：A thermoplastic elastomer patch matrix for traditional Chinese medicine: design and evaluation

作者：Wang, Chengxiao[1,2];Ma, Jianfang[3];Liu, Ran[1,2];Han, Wei[1];Tang, Xiuzhen[2]

机构：[1]E China Univ Sci & Technol, Sch Pharm, Shanghai 200237, Peoples R China;[2]Natl Engn Res Ctr Tradit Chinese Med, Shanghai 201203, Peoples R China;[3]Natl Pharmaceut Engn & Res Ctr, Shanghai, Peoples R China

年份：2014

卷号：40

期号：2

起止页码：211

外文期刊名：DRUG DEVELOPMENT AND INDUSTRIAL PHARMACY

收录：;WOS:【SCI-EXPANDED(收录号:WOS:000331258400009)】；

基金：This research was supported by the National Science and Technology Key Program for the 11th five-year Plan of China (2008BAI53B075).

语种：英文

外文关键词：Capsaicin; formulation optimization; methyl salicylate; skin permeation; thermoplastic elastomer; traditional Chinese medicine

摘要：Objective: To design and evaluate a novel pressure sensitive adhesive (PSA) patch containing traditional Chinese medicine (TCM) using styrene-isoprene-styrene (SIS) copolymer. Method: A mixture D-optimal design with ternary response surface diagram was employed in the optimization process. The proportions of SIS copolymer, tackifying resin and plasticizer were selected as the independent variables while tack force, peel strength of the patch and skin penetrability of methyl salicylate were selected as the dependent variables. The optimized patch was then evaluated including in vivo absorption, pharmacological activities and skin irritation, by comparing with a commercial patch based on natural rubber. Results: The optimized patch, which comprised 30.0% SIS copolymer, 26.6% tackifying resin and 43.4% plasticizer, was superior to commercial patch in skin permeation, pharmacological activities and skin biocompatibility. Conclusion: SIS copolymer was a suitable substitute to natural rubber in producing patches containing TCM formula.