文献类型：期刊文献

中文题名：Fmoc-DOPA(acetonide)-OH的简单高效合成

英文题名：Simple and Cost-Effective Synthesis of Fmoc-DOPA(acetonide)-OH

作者：刘晶晶[1];张东辉[1];江伟男[1];刘润辉[1,2]

机构：[1]华东理工大学材料科学与工程学院,超细材料重点实验室,特种功能高分子材料及相关技术重点实验室,上海200237;[2]复旦大学高分子科学系,上海200438

年份：2020

卷号：40

期号：8

起止页码：2543

中文期刊名：有机化学

外文期刊名：Chinese Journal of Organic Chemistry

收录：CSTPCD;;Scopus;WOS:【SCI-EXPANDED(收录号:WOS:000581125800035)】；北大核心:【北大核心2017】；CSCD:【CSCD2019_2020】；

基金：Project supported by the National Natural Science Foundation of China (Nos. 21774031, 31800801), the Natural Science Foundation of Shanghai City (No. 18ZR1410300), and the Fundamental Research Funds for the Central Universities (Nos. 22221818014, 50321041917001).

语种：中文

中文关键词：贻贝粘附蛋白;3;4-二羟基苯丙氨酸(DOPA);Fmoc-DOPA(acetonide)-OH;简单高效合成

外文关键词：mussel adhesion protein;3;4-dihydroxyphenylalanine(DOPA);Fmoc-DOPA(acetonide)-OH;simple and efficient synthesis

摘要：受贻贝粘附蛋白启发而产生的3,4-二羟基苯丙氨酸(DOPA)衍生物引起了人们对生物材料和医疗器械的功能化涂层产生广泛兴趣.芴甲氧羰酰基-3,4-二羟基缩丙酮-L-苯丙氨酸[Fmoc-DOPA(acetonide)-OH]是贻贝粘附蛋白和多肽的固相合成关键原料.然而,现有的Fmoc-DOPA(acetonide)-OH的合成方法步骤繁琐、成本高,使其实际应用受到极大阻碍.本工作报道的两步法策略制备Fmoc-DOPA(acetonide)-OH,是一种简单且经济高效的合成方法,具有广阔的应用前景.
3,4-Dihydroxyphenylalanine(DOPA)derivatives inspired by mussels have attracted broad interest in functional coatings of biomaterials and biomedical devices.Fmoc-DOPA(acetonide)-OH is the key precursor for solid-phase synthesis of adhesive mussel proteins and peptides.However,existing synthesis methods of Fmoc-DOPA(acetonide)-OH were tedious and costly which greatly hindered its practical application.Herein,a simple two-step strategy for preparing Fmoc-DOPA-(acetonide)-OH is reported,which is a simple and cost-effective synthesis method with broad application prospects.