文献类型：期刊文献

英文题名：Enhanced infarct myocardium repair mediated by thermosensitive copolymer hydrogel-based stem cell transplantation

作者：Xia, Yu[1,2,3];Zhu, Kai[1,2];Lai, Hao[1,2];Lang, Meidong[4];Xiao, Yan[4];Lian, Sheng[4];Guo, Changfa[1,2];Wang, Chunsheng[1,2]

机构：[1]Fudan Univ, Zhongshan Hosp, Dept Cardiac Surg, Shanghai 200032, Peoples R China;[2]Shanghai Inst Cardiovasc Dis, Shanghai 200032, Peoples R China;[3]Zunyi Med Coll, Affiliated Hosp, Dept Cardiothorac Surg, Zunyi 563003, Peoples R China;[4]E China Univ Sci & Technol, Sch Mat Sci & Engn, Minist Educ, Key Lab Ultrafine Mat, Shanghai 200237, Peoples R China

年份：2015

卷号：240

期号：5

起止页码：593

外文期刊名：EXPERIMENTAL BIOLOGY AND MEDICINE

收录：;WOS:【SCI-EXPANDED(收录号:WOS:000354325700006)】；

基金：We would thank Jianguo Jia from Fudan University, for his help on animal care and assistance with histology. The paper was supported by the National Science Foundation of China (Grant Nos.: 81000042, 81270326 and 81301312) and Shanghai Science Foundation (Grant No.: 10ZR1406200).

语种：英文

外文关键词：Copolymer; hydrogel; mesenchymal stem cells; myocardial infarction; cardiac repair

摘要：Mesenchymal stem cell (MSC) transplantation by intramyocardial injection has been proposed as a promising therapy strategy for cardiac repair after myocardium infarction. However, low retention and survival of grafted MSCs hinder its further application. In this study, copolymer with N-isopropylacrylamide/acrylic acid/2-hydroxylethyl methacrylate-poly(epsilon-caprolactone) ratio of 88:9.6:2.4 was bioconjugated with type I collagen to construct a novel injectable thermosensitive hydrogel. The injectable and biocompatible hydrogel-mediated MSC transplantation could enhance the grafted cell survival in the myocardium, which contributed to the increased neovascularization, decreased interstitial fibrosis, and ultimately improved heart function to a significantly greater degree than regular MSC transplantation. We suggest that this novel hydrogel has the potential for future stem cell transplantation.