文献类型：期刊文献

英文题名：Bfbsa– a Newly Developed Reagent for the Bromination of (Het)Arenes, Drugs and Natural Products Under Mild Conditions

作者：Li, Chaolin[1]; Yang, Xianjin[1]

机构：[1] Key Lab for Advanced Material, Institute of Fine Chemicals, East China University of Science and Technology, 130 Meilong Road, Shanghai, 200231, China

年份：2024

外文期刊名：SSRN

收录：EI(收录号：20240408002)

语种：英文

摘要：A newly developed brominating reagent BFBSA(N-bromo-N-fuorobenzenesulfonylamide) for the bromination of (Het)arenes, drugs and natural products in high selectivity and efficiency was reported. This versatile protocol was conducted under mild conditions with the characteristics of wide substrates scope and excellent functional group tolerance, broadening the methodologies of the late-stage modification of complex molecules. And the characteristics like ready availability, low cost and unsensitivity to air and moisture of BFBSA reagent exhibit the potential application in the drug discovery. ? 2024, The Authors. All rights reserved.