文献类型：期刊文献

英文题名：Phototriggered labeling and crosslinking by 2-nitrobenzyl alcohol derivatives with amine selectivity

作者：Wang, Chenxi[1];Liu, Yuan[1];Bao, Chunyan[1];Xue, Yuan[1];Zhou, Yaowu[1];Zhang, Dasheng[1];Lin, Qiuning[1];Zhu, Linyong[1]

机构：[1]East China Univ Sci & Technol, Sch Chem & Mol Engn, Shanghai Key Lab Funct Mat Chem, Shanghai 200237, Peoples R China

年份：2020

卷号：56

期号：15

起止页码：2264

外文期刊名：CHEMICAL COMMUNICATIONS

收录：;EI(收录号：20200908247944);WOS:【SCI-EXPANDED(收录号:WOS:000517182900005)】；

基金：This work was supported by the National Natural Science Foundation of China (NSFC) (21425311 and 21907029) and the National Key Research and Development Project (2019YFA0110500).

语种：英文

外文关键词：Crosslinking - Photoreactivity

摘要：Here we report the use of 2-nitrobenzyl alcohol (NB) as a photoreactive group with amine selectivity and explore its applications for photoaffinity labeling and crosslinking of biomolecules. This work confirms that NB is an efficient photoreactive group and has great potential in drug discovery, chemical biology and protein engineering.