文献类型：期刊文献

英文题名：Circularization of Aptamer Nanomedicine Improves Nuclease Resistance, Targeted Recognition, and Transdermal Effect for Topical Psoriasis Therapy

作者：Liu, Zhe[1];Xu, Yao[1];Qian, Yuyan[1];Fan, Yu[1];Fan, Zhen[1];Du, Jianzhong[2,3,4];Hu, Yong[1]

机构：[1]Tongji Univ, Sch Mat Sci & Engn, Dept Polymer Mat, Shanghai 201804, Peoples R China;[2]Tongji Univ, Dept Gynaecol & Obstet, Shanghai Key Lab Anesthesiol & Brain Funct Modulat, Clin Res Ctr Anesthesiol & Perioperat Med,Translat, Shanghai 200434, Peoples R China;[3]Tongji Univ, Sch Mat Sci & Engn, Minist Educ, Key Lab Adv Civil Engn Mat, Shanghai 201804, Peoples R China;[4]East China Univ Sci & Technol, Sch Mat Sci & Engn, Shanghai 200237, Peoples R China

年份：2025

卷号：25

期号：22

起止页码：9139

外文期刊名：NANO LETTERS

收录：;EI(收录号：20252218497562);WOS:【SCI-EXPANDED(收录号:WOS:001494665300001)】；

基金：This project is supported by the National Natural Science Foundation of China (52373154 and 22335005), National Key R&D Program of China (2022YFC2402900), Innovation Program of Shanghai Municipal Education Commission (2023ZKZD28), Interdisciplinary Project in "Medicine + X" of Tongji University, and Fundamental Research Funds for the Central Universities. Y.H. is the recipient of National Natural Science Fund for Excellent Young Scientists Fund Program (overseas). J.D. is the recipient of National Natural Science Fund for Distinguished Young Scholars.

语种：英文

外文关键词：Circularization; TNF-alpha aptamer; VEGFaptamers; aptamer nanomedicine; psoriasis therapy

摘要：Inhibiting excessive hyperproliferation and inflammatory responses of keratinocytes are two primary tasks against psoriasis, which, however, have not been well integrated by the current available nanomedicines. Herein, we develop a nucleic acid nanomedicine through coassembly of circular aptamers and gold nanoclusters via electrostatic interactions for psoriasis therapy. After topical application, this nanomedicine bearing vascular endothelial growth factor (VEGF) and tumor necrosis factor alpha (TNF-alpha) aptamers crosses the stratum corneum and enters the deep layers of psoriatic site, from which it specifically inhibits VEGF-mediated keratinocyte proliferation and TNF-alpha-mediated inflammatory responses simultaneously. More importantly, the circular aptamers further promote the nuclease resistance, targeted recognition, and transdermal effect of the nanomedicine, as compared to their linear counterparts. These improved synergistic actions effectively prevent and cure psoriasis of mice induced by imiquimod. It is anticipated that this study provides a general strategy for targeted regulation of intricate pathological microenvironments beyond psoriasis.