文献类型：期刊文献

英文题名：Novel antibacterial cellulose diacetate-based composite 3D scaffold as potential wound dressing

作者：Liang, Wencheng[1,3];Jiang, Mingli[2];Zhang, Junyong[3];Dou, Xiaoming[1];Zhou, Yan[2];Jiang, Yun[5];Zhao, Li[4];Lang, Meidong[3]

机构：[1]East China Univ Sci & Technol, Ctr Photon Biomed Diag, Sch Sci, Shanghai 200237, Peoples R China;[2]East China Univ Sci & Technol, Sch Biotechnol, State Key Lab Bioreactor Engn, Shanghai 200237, Peoples R China;[3]East China Univ Sci & Technol, Sch Mat Sci & Engn, Minist Educ, Key Lab Ultrafine Mat,Shanghai Key Lab Adv Polyme, Shanghai 200237, Peoples R China;[4]East China Univ Sci & Technol, New World Inst Biotechnol, State Key Lab Bioreactor Engn, Shanghai 200237, Peoples R China;[5]Zhejiang Univ Technol, Lib, Hangzhou 310023, Peoples R China

年份：2021

卷号：89

起止页码：225

外文期刊名：JOURNAL OF MATERIALS SCIENCE & TECHNOLOGY

收录：;EI(收录号：20210109710674);WOS:【SCI-EXPANDED(收录号:WOS:000694802100004)】；

基金：This research was financially supported by the National Key Research and Development Program (No. 2016YFC1100703) ; the authors thank Research Center of Analysis and Test of East China University of Science and Technology for the help in characteriza-tion.

语种：英文

外文关键词：Cellulose diacetate; Electrospinning; 3D scaffold; Wound dressing

摘要：In this work, novel antibacterial cellulose diacetate/poly(ethylenimine)/hyaluronic acid (CDA/PEI/HA) composite three-dimension (3D) scaffolds were prepared through electrospinning and post-processing. Firstly, CDA/PEI 2D composite nanofiber membranes were prepared by electrospinning, and then the CDA/PEI/HA 3D composite scaffolds were fabricated by post-processing and freeze-drying of CDA/PEI membranes. In particular, HA was added to improve the biocompatibility of composite scaffolds. Compared with CDA/PEI scaffolds, CDA/PEI/HA composite scaffolds showed higher water absorbing rate, higher water retention rate and higher mechanical strength. Moreover, CDA/PEI/HA composite scaffolds with abundant positive charge were benefit for improving antibacterial activity. CDA/PEI/HA scaffolds with biology function of HA were benefit for improving hemocompatibility and cell proliferation of CDA/PEI scaffolds. In summary, antibacterial CDA/PEI/HA scaffolds could protect wound from bacterial infection, improve cellular behavior and accelerate wound healing. Thus, CDA/PEI/HA scaffolds could be potential application for wound dressing. (c) 2021 Published by Elsevier Ltd on behalf of The editorial office of Journal of Materials Science & Technology.