文献类型：会议论文

英文题名：Analysis and optimization of determining factors in irreversible electroporation for large ablation zones without thermal damage

作者：Yang, Yongji[1]; Zhang, Bing[2]; Moser, Michael[3]; Zhang, Edwin[4]; Zhang, Wenjun[5]

机构：[1] Tumor Ablation Group, CISR Lab., East China University of Science and Technology, Shanghai, China; [2] Division of Biomedical Engineering, University of Saskatchewan, Saskatoon, Canada; [3] Department of Surgery, University of Saskatchewan, Saskatoon, Canada; [4] Division of Vascular and Interventional Radiology, Department of Medical Imaging, University of Toronto, Canada; [5] Department of Mechanical Engineering, University of Saskatchewan, Saskatoon, Canada

会议论文集：ASME 2017 International Mechanical Engineering Congress and Exposition, IMECE 2017

会议日期：November 3, 2017 - November 9, 2017

会议地点：Tampa, FL, United states

语种：英文

外文关键词：Analysis of variance (ANOVA) - Surface properties - Sustainable development - Finite element method - Electrodes

摘要：The aim of this study was to analyze five factors that are responsible for the ablation volume and maximum temperature during the procedure of irreversible electroporation (IRE). The five factors used in this study were the pulse strength (U), the electrode diameter (B), the distance between the electrode and the center (D), the electrode length (L), and the number of electrodes (N). A validated finite element model of IRE was built to collect the data of the ablation volume and maximum temperature generated in a liver tissue. Twenty-five experiments were performed, in which the ablation volume and maximum temperature were taken as response variables. The five factors with ranges were analyzed to investigate their impacts on the ablation volume and maximum temperature, respectively, using analysis of variance (ANOVA). Response surface method (RSM) was used to optimize the five factors for the maximum ablation volume without thermal damage (the maximum temperature ≤ 50 °C). U, and L were found with significant impacts on the ablation volume (P 3 without thermal damage can be obtained by using the following set of factors: U = 2362.2384 V, B = 1.4889 mm, D = 7 mm, L = 4.5659 mm, and N = 3. The study concludes that both B and N have insignificant impacts (P = 0.886, and P = 0.279, respectively) on the ablation volume; U has the most significant impact (P ? Copyright 2017 ASME.