文献类型：期刊文献

中文题名：钯催化甲基苯基膦氢的不对称烷基化反应合成含膦手性中心化合物

英文题名：Pd-Catalyzed Asymmetric Alkylation of Methylphenylphosphine with Alkyl Halides for the Synthesis of P-stereogenic Compounds

作者：李春[1];李伟逊[2];许胜[1];段伟良[2]

机构：[1]华东理工大学化学与分子工程学院,上海200237;[2]中国科学院上海有机化学研究所金属有机化学国家重点实验室,上海200032

年份：2013

卷号：33

期号：4

起止页码：799

中文期刊名：有机化学

外文期刊名：Chinese Journal of Organic Chemistry

收录：CSTPCD;;Scopus;WOS:【SCI-EXPANDED(收录号:WOS:000318460600014)】；北大核心:【北大核心2011】；CSCD:【CSCD2013_2014】；

基金：Project supported by the National Basic Research Program of China (973 Program, 2010CB833300), the National Natural Science Foundation of China (Nos. 20902099, 21172238), and the Found of Shanghai Institute of Organic Chemistry, Chinese Academy of Sciences.

语种：中文

中文关键词：膦手性化合物;Pincer-钯催化剂;甲基苯基膦氢;不对称烷基化

外文关键词：P-stereogenic compound; Pincer-Pd catalyst; methylphenylphosphine; asymmetric alkylation

摘要：研究了Pincer-钯催化的甲基苯基膦氢对卤代烃的不对称取代反应.以高收率、中等的立体选择性得到含膦手性中心的膦化合物,同时对反应的催化循环和可能的立体化学过程进行了探讨.
A bis（phosphine） （PCP） pincer palladium-catalyzed asymmetric alkylation of methylphenylphosphine with alkyl halides was developed for the synthesis of P-chiral phosphorus compounds in mild conditions. The corresponding products were obtained in high yields with moderate enantioselectivities. The possible catalytic cycle and stereochemical pathway have also been proposed via the Pincer-PdPMe（Ph） intermediate, which is generated from the reaction of Pd catalyst with methyl- phenylphosphine.