文献类型：期刊文献

英文题名：A trident-like multi-cationic photosensitizer with stabilized membrane camouflage for efficient tumor-targeted photodynamic therapy

作者：Yi, Guofeng[1,2];Li, Jiayi[1,2];Xu, Qiqi[1,2];Wang, Ying[1,2,3];Peng, Chen[4];Zhao, Weijun[1,2,3];Wang, Cheng-Yun[1,2,3]

机构：[1]East China Univ Sci & Technol, Feringa Nobel Prize Scientist Joint Res Ctr, Frontiers Sci Ctr Materiobiol & Dynam Chem, Inst Fine Chem,Key Lab Adv Mat,Sch Chem & Mol Engn, Shanghai 200237, Peoples R China;[2]East China Univ Sci & Technol, Feringa Nobel Prize Scientist Joint Res Ctr, Shanghai Key Lab Funct Mat Chem,Frontiers Sci Ctr, Inst Fine Chem,Sch Chem & Mol Engn,Joint Int Res L, Shanghai 200237, Peoples R China;[3]East China Univ Sci & Technol, Ctr Photosensit Chem Engn, Shanghai 200237, Peoples R China;[4]Fudan Univ, Shanghai Publ Hlth Clin Ctr, Dept Radiol, Shanghai 201411, Peoples R China

年份：2025

卷号：61

期号：68

起止页码：12733

外文期刊名：CHEMICAL COMMUNICATIONS

收录：;EI(收录号：20253419020157);WOS:【SCI-EXPANDED(收录号:WOS:001540795400001)】；

基金：This work was supported by the National Natural Science Foundation of China (9235630033 and 22105069), the Shanghai Natural Science Foundation (No. 22ZR1417300), and the Innovation Program of Shanghai Municipal Education Commission (2023FGS01).

语种：英文

外文关键词：Camouflage - Dyes - Excited states - Photosensitizers - Tumors

摘要：We develop a unique trident-like multi-cationic photosensitizer (PS) with an acceptor-donor-acceptor (A-D-A) structure to enhance photodynamic therapy (PDT). The design minimizes PS leakage from membrane camouflaged nanoparticles (<1% in 24 h) via hydrophilic anchoring, while boosting ROS generation (13.8-fold higher O-1(2) than Rose Bengal) through excited state optimization, thus significantly improving tumor-targeted PDT efficiency.