文献类型：期刊文献

英文题名：Redox-responsive supramolecular amphiphiles based on a pillar[5]arene for enhanced photodynamic therapy

作者：Chen, Ye[1];Rui, Leilei[1];Liu, Lichao[1];Zhang, Weian[1]

机构：[1]E China Univ Sci & Technol, Shanghai Key Lab Funct Mat Chem, 130 Meilong Rd, Shanghai 200237, Peoples R China

年份：2016

卷号：7

期号：19

起止页码：3268

外文期刊名：POLYMER CHEMISTRY

收录：;EI(收录号：20162202449594);WOS:【SCI-EXPANDED(收录号:WOS:000375701700010)】；

基金：This work was financially supported by the National Natural Science Foundation of China (no. 21574039), Research Innovation Program of SMEC (no. 14ZZ065) and Shanghai Pujiang Program under 14PJ1402600. W. Z. also acknowledges the support from the Fundamental Research Funds for the Central Universities.

语种：英文

外文关键词：Controlled drug delivery - Micelles - Solutions - Hydrogen bonds - Porphyrins - Photodynamic therapy - Photosensitizers - Covalent bonds - High resolution transmission electron microscopy - Sulfur compounds - Targeted drug delivery - Amphiphiles - Dynamic light scattering - Supramolecular chemistry

摘要：Supramolecular amphiphiles based on a pillar[5]arene with enhanced photodynamic therapy have been fabricated. Supramolecular amphiphiles based on host-guest complexation between a poly(ethylene glycol)-functionalized pillar[5]arene (PEG-P[5]a) and a pyridinium-terminated porphyrin derivative bearing a disulfide bond (TPPC6-SS-Py) could self-assemble into spherical micelles in aqueous solution with good colloidal stability as confirmed by transmission electron microscopy (TEM) and dynamic light scattering (DLS). Also, PEG-P[5]a/TPPC6-SS-Py micelles exhibited rapid release of porphyrin photosensitizers in a reducing environment. In addition, these micelles demonstrated nearly no toxicity in the dark but a higher photocytotoxicity upon light irradiation evaluated by the MTT assay. Flow cytometry and confocal laser scanning microscopy (CLSM) revealed a more effective cellular uptake property compared with free porphyrin. Therefore, novel reduction-responsive supramolecular amphiphiles with rapid drug release and superior cell internalization ability are constructed, which may provide a platform for drug delivery systems.