文献类型：期刊文献

英文题名：Copper Promoted Aerobic Oxidative C(sp3)-C(sp3) Bond Cleavage of N-(2-(Pyridin-2-yl)-ethyl)anilines

作者：Yu, Yang[1];Zhang, Yong[1];Sun, Chengyu[1];Shi, Lei[3];Wang, Wei[1,2];Li, Hao[1]

机构：[1]East China Univ Sci & Technol, Shanghai, Peoples R China;[2]Univ Arizona, Tucson, AZ 85721 USA;[3]Firmenich Aromat China Co Ltd, Shanghai, Peoples R China

年份：2020

卷号：85

期号：4

起止页码：2725

外文期刊名：JOURNAL OF ORGANIC CHEMISTRY

收录：;EI(收录号：20201108276118);WOS:【SCI-EXPANDED(收录号:WOS:000516665800086)，CCR-EXPANDED(收录号:WOS:000516665800086)】；

基金：This work was supported by the National Natural Science Foundation of China (Grants 21572054, 21572055, and 21738002), the program for Professor of Special Appointment (Eastern Scholar) at Shanghai Institutions of Higher Learning, the Fundamental Research Funds for the Central Universities, and the China 111 Project (Grant B07023).

语种：英文

外文关键词：Copper - Stem cells

摘要：A strategy of aerobic oxidative C(sp(3))-C(sp(3)) bond cleavage of N-ethylaniline derivatives bearing azaarenes for the synthesis of N-aryl formamides has been developed. This approach was carried out smoothly with the CuI/TEMPO/air system to give N-aryl formamides in yields of 50-90%. With this methodology, a mutagenically active compound was constructed in 90% yield. Moreover, the reaction also provided a one-pot synthetic tool for accessing a promoter of hematopoietic stem cells by difunctionalization in 61% yield.