文献类型：期刊文献

英文题名：New cryptotanshinone derivatives with anti-influenza A virus activities obtained via biotransformation by Mucor rouxii

作者：He, Wenni[1,2,3];Li, Yao[1,4];Qin, Yuejie[1];Tong, Xiaomei[1];Song, Zhijun[1,4];Zhao, Yu[1,4];Wei, Ran[1];Li, Li[3,5];Dai, Huanqin[1];Wang, Wenzhao[6];Luo, Houwei[7];Ye, Xin[1];Zhang, Lixin[8,9];Liu, Xueting[8]

机构：[1]Chinese Acad Sci, Inst Microbiol, Key Lab Pathogen Microbiol & Immunol, Beijing 100101, Peoples R China;[2]Chinese Acad Med Sci, Inst Med Biotechnol, China Pharmaceut Culture Collect, Beijing 100050, Peoples R China;[3]Peking Union Med Coll, Beijing 100050, Peoples R China;[4]Univ Chinese Acad Sci, Beijing 100049, Peoples R China;[5]Chinese Acad Med Sci, Inst Mat Med, Dept Med Chem, Beijing 100050, Peoples R China;[6]Chinese Acad Sci, Inst Microbiol, State Key Lab Mycol Chem, Beijing, Peoples R China;[7]China Pharmaceut Univ, Dept Nat Prod, Nanjing 210009, Jiangsu, Peoples R China;[8]East China Univ Sci & Technol, State Key Lab Bioreactor Engn, Shanghai 200237, Peoples R China;[9]Qingdao Natl Lab Marine Sci & Technol, Lab Marine Biol & Biotechnol, Qingdao, Shandong, Peoples R China

年份：2017

卷号：101

期号：16

起止页码：6365

外文期刊名：APPLIED MICROBIOLOGY AND BIOTECHNOLOGY

收录：;EI(收录号：20172303739287);WOS:【SCI-EXPANDED(收录号:WOS:000407077400007)】；

基金：This work was supported by the National Natural Science Foundation of China (31430002, 81573341, 31400090, 31320103911), the National Major Scientific and Technological Special Project for Significant New Drugs Development of China (2015ZX09J15102-004), the National Institutes of Health (GM40541), the Welch Foundation (F-1511), the European Union's Seventh Framework Programme (FP7/2007-2013) under grant agreement no. 312184, and the CAMS Innovative Medicine (CAMS-I2M) (No. 2016-I2M-2-002, 2016-I2M-2-003).

语种：英文

外文关键词：Cryptotanshinone; Biotransformation; Mucor rouxii; Anti-influenza A virus activity

摘要：This paper provides an efficient platform to diversify the structure and pharmaceutical potentials of known natural products. Seven metabolites were obtained via the biotransformation of cryptotanshinone by the fungus Mucor rouxii AS 3.3447, and assigned as 13R-14R-hydroxy-anhydride of 16Rcryptotanshinone (1), 1S-hydroxy-anhydride of 16Rcryptotanshinone (2), 1R-hydroxy-anhydride of 16Rcryptotanshinone (3), 3S-hydroxy-epicryptoacetalide (4), 3S-hydroxy- cryptoacetalide (5), epicryptoacetalide (6), and cryptoacetalide (7). Among these compounds, 1-5 are novel. The ortho-naphthoquinone chromophore of cryptotanshinone was degraded and rearranged by M. rouxii. 1 and 3 showed good anti-influenza Avirus activities with the reduced cytotoxic activities compared to the parent substrate cryptotanshinone (8). The structures of all the new compounds were determined on the basis of HRESIMS (high-resolution electrospray ionization mass spectroscopy) spectrometry, NMR (nuclear magnetic resonance) spectroscopy, ECD (electronic circular dichroism) calculations, and the CD (circular dichroism) of "in situ" method with [Rh-2(OCOCF3)(4)].