文献类型：期刊文献

英文题名：A flexible plasmonic SERS hydrogel patch for metabolite sensing on bio-interfaces

作者：Yang, Yide[1,2];Su, Zehou[1,2];Liu, Xuanting[1,2];Song, Jiaying[1,2];Li, Chunchun[3];Xu, Yikai[4];Ye, Jian[1,2,5,6];Lin, Linley Li[1,2]

机构：[1]Shanghai Jiao Tong Univ, Peoples Hosp 6, Sch Med, Shanghai 200030, Peoples R China;[2]Shanghai Jiao Tong Univ, Sch Biomed Engn, Shanghai 200030, Peoples R China;[3]East China Univ Sci & Technol, Sch Mat Sci & Engn, Shanghai 200237, Peoples R China;[4]East China Univ Sci & Technol, Key Lab Adv Mat & Feringa Nobel Prize Scientist Jo, Frontiers Sci Ctr Materiobiol & Dynam Chem, Sch Chem & Mol Engn, Shanghai 200237, Peoples R China;[5]Shanghai Jiao Tong Univ, Renji Hosp, Sch Med, Shanghai Key Lab Gynecol Oncol, Shanghai 200127, Peoples R China;[6]Shanghai Jiao Tong Univ, Tongren Hosp, Inst Med Robot, Shanghai Key Lab Flexible Med Robot, Shanghai 200336, Peoples R China

年份：2026

卷号：18

期号：6

起止页码：3105

外文期刊名：NANOSCALE

收录：;EI(收录号：20260319938172);WOS:【SCI-EXPANDED(收录号:WOS:001664568300001)】；

基金：This work was supported by the National Key Research and Development Program of China (No. 2024YFF1502600), the National Natural Science Foundation of China (No. 82272054, 82372016, and 22402060), the Science and Technology Commission of Shanghai Municipality (No. 24DIPA00300, 24490710800, and 24ZR1416700), the Fundamental Research Funds for the Central Universities (No. YG2024LC09, YG2024QNA15, and YG2025ZD25), the Research Fund of Shanghai Key Laboratory of Flexible Medical Robotics (SKLFMR-103), and the Shanghai Key Laboratory of Gynecologic Oncology.

语种：英文

外文关键词：Biochemistry - Biomolecules - Durability - Flexible structures - Interfaces (materials) - Metabolites - Plasmonic nanoparticles - Plasmonics - Raman spectroscopy - Tissue

摘要：The growing demand for real-time, non-invasive monitoring of biochemical molecules has driven the development of advanced, flexible sensing materials. Surface-enhanced Raman spectroscopy (SERS) offers high molecular specificity and ultralow detection limits. While rigid SERS substrates based on plasmonic nanoparticle arrays provide strong signal enhancements, they lack the mechanical compatibility and conformal adhesion required for dynamic biological surfaces, such as human skin or neural tissues. Here, we present a flexible SERS hydrogel patch for the label-free detection of metabolites at bio-interfaces. The patch integrates a self-assembled silver nanoparticle film with an ultrathin polyvinyl alcohol (PVA) hydrogel layer to achieve good plasmonic enhancement, mechanical durability, conformity and reliable SERS stability. The SERS patch allows the detection of metabolites within 6 min upon analyte exposure, enabling the label-free detection of key metabolites, such as glucose, uric acid and urea with concentrations down to 1 mu M, 50 mu M and 1 mM, respectively. We demonstrate the versatility of this platform by performing ex vivo experiments on porcine brain and muscle tissues to simulate real-world application scenarios in brain-machine interfaces and implantable sensors. This work demonstrates the feasibility of SERS hydrogel-based flexible platforms for the in situ monitoring of metabolites at bio-interfaces.