文献类型：期刊文献

英文题名：A Turn-On Aie Fluorescent Probe with Large Stokes Shift for Peroxynitrite Detection and Imaging in Living Cells

作者：Wang, Cheng-Yun[1]; Zhu, Xu-Zhong[1]; Zhang, Zhen[1]; Dong, Rui[1]; Chen, Yun[1]; Wu, Yi-Yang[1]

机构：[1] Key Laboratory for Advanced Materials, Institute of Fine Chemicals, School of Chemistry and Molecular Engineering, East China University of Science and Technology, 130 Meilong Road, Shanghai, 200237, China

年份：2023

外文期刊名：SSRN

收录：EI(收录号：20230264180)

语种：英文

外文关键词：Fluorescence - Fluorescence spectroscopy

摘要：Peroxynitrite (ONOO-), as an important reactive oxygen species (ROS), plays a significant role in pathological and physiological processes, and abnormal levels of ONOO? will lead to many diseases. Thus, novel fluorescent probe for detecting ONOO- is in urgent need. Herein, we constructed a probe TPPB with aggregation-induced emission (AIE) characteristic based on triphenylamine and boronate group. The probe TPPB possesses remarkable performances including high selectivity in the presence of other ROSs, low detection limit (32 nM) and large Stokes shift (215 nm) toward ONOO-. Besides, probe TPPB shows low cytotoxicity and good imaging ability of ONOO- in living cells ? 2023, The Authors. All rights reserved.