文献类型：期刊文献

英文题名：miR-139-5p reverses stemness maintenance and metastasis of colon cancer stem-like cells by targeting E2-2

作者：Ma, Xiaoying[1,2];Liu, Jiajun[1,2];Li, Jiyu[3];Li, Yueqi[1,2];Van Minh Le[4];Li, Shaoyu[5];Liang, Xin[1,2];Li, Lingshuang[6];Liu, Jianwen[1,2]

机构：[1]East China Univ Sci & Technol, State Key Lab Bioreactor Engn, Sch Pharm, Shanghai 200237, Peoples R China;[2]East China Univ Sci & Technol, Shanghai Key Lab New Drug Design, Sch Pharm, Shanghai 200237, Peoples R China;[3]Tongji Univ, Sch Med, Shanghai Peoples Hosp 10, Dept Gen Surg, Shanghai, Peoples R China;[4]Natl Inst Med Mat, Res Ctr Ginseng & Med Mat, Ho Chi Minh City, Vietnam;[5]Xinjiang Med Univ, Affiliated Hosp 3, Dept Clin Lab, Urumqi, Xinjiang, Peoples R China;[6]Shanghai Univ Tradit Chinese Med, Dept Oncol, Longhua Hosp, Shanghai 200032, Peoples R China

年份：2019

卷号：234

期号：12

起止页码：22703

外文期刊名：JOURNAL OF CELLULAR PHYSIOLOGY

收录：;WOS:【SCI-EXPANDED(收录号:WOS:000484376600108)】；

基金：Science and Technology Commission of Shanghai Municipality, Grant/Award Number: 17430741600; National Natural Science Foundation of China, Grant/Award Numbers: 81860378, 81502600

语种：英文

外文关键词：CD133+/CD44+; colon cancer; EMT; metastasis; stemness

摘要：Colon cancer stem cells (CCSCs) stand for a critical subpopulation of colon cancer cells that possess self-renewal and multilineage differentiation potentials and drive tumorigenicity. Due to their impact on treatment tolerance, CCSCs have been a hot research topic in the past few years. We have previously reported that miR-139-5p is a vital tumor repressive noncoding RNA whose level decreases in the clinical colon cancer samples with the increase of tumor malignancy. This research discovered that miR-139-5p targets the Wnt/beta-catenin/TCF7L2 downstream effector E2-2 in CCSCs. E2-2 is a pivot molecule in the negative feedback loop of miR-139-5p/Wnt/beta-catenin/TCF7L2. Its small interfering RNA reverses the stemness maintenance and epithelial-mesenchymal transition of colon cancer CSCs. This study provides a theoretical foundation for the clinical diagnosis and medical treatment of recurrent or metastatic colon cancer with miR-139-5p and its target E2-2.