文献类型：期刊文献

英文题名：Nickel-catalyzed Suzuki-Miyaura type cross-coupling reactions of (2,2-difluorovinyl)benzene derivatives with arylboronic acids

作者：Xiong, Yang[1];Huang, Tao[1];Ji, Xinfei[1];Wu, Jingjing[2];Cao, Song[1]

机构：[1]E China Univ Sci & Technol, Sch Pharm, Shanghai Key Lab Chem Biol, Shanghai 200237, Peoples R China;[2]Shanghai Inst Technol, Sch Chem & Environm Engn, Shanghai 201418, Peoples R China

年份：2015

卷号：13

期号：27

起止页码：7389

外文期刊名：ORGANIC & BIOMOLECULAR CHEMISTRY

收录：;EI(收录号：20154801603243);WOS:【SCI-EXPANDED(收录号:WOS:000357414400004)，CCR-EXPANDED(收录号:WOS:000357414400004)】；

基金：We are grateful for financial supports from the National Natural Science Foundation of China (Grant No. 21472043, 21272070, and 21302128). Additionally, we also thank Prof. Jianwen Liu (School of Pharmacy, East China University of Science and Technology, Shanghai, China) for bioassay assistance.

语种：英文

外文关键词：Benzene - Catalysis - Nickel compounds

摘要：An unprecedented highly stereoselective example of nickelcatalyzed Suzuki-Miyaura type cross-coupling reactions of (2,2-difluorovinyl)benzene derivatives with arylboronic acids was developed. The reaction proceeded efficiently in the presence of 5 mol% NiCl2(PCy3)(2) and K3PO4, affording the Z-fluorostyrene derivatives in good to high yields with excellent regioselectivity.