文献类型：期刊文献

英文题名：A confined crosslinking strategy towards an intelligent organosilica-micellar hybrid drug delivery system

作者：Qin, Xing[1];Qin, Limei[1];He, Jianping[1];Wang, Qinghua[1];Li, Yongsheng[1,2];Niu, Dechao[1]

机构：[1]East China Univ Sci & Technol, Frontier Sci Ctr Mat Biol & Dynam Chem, Sch Mat Sci & Engn, Low Dimens Mat Chem Lab,Key Lab Ultrafine Mat,Min, Shanghai 200237, Peoples R China;[2]Shihezi Univ, Sch Chem & Chem Engn, Key Lab Green Proc Chem Engn Xinjiang Bingtuan, Shihezi 832003, Peoples R China

年份：2022

卷号：10

期号：2

起止页码：524

外文期刊名：BIOMATERIALS SCIENCE

收录：;EI(收录号：20220611586862);WOS:【SCI-EXPANDED(收录号:WOS:000729925200001)】；

基金：This work was financially supported by the National Natural Science Foundation of China for Innovative Research Groups (no. 51621002), the National Natural Science Foundation of China (nos 52072124 and 51972112), the Shanghai Municipal Science and Technology Major Project (grant 2018SHZDZX03), the Natural Science Foundation of Shanghai (no. 20ZR1414900), Leading Talents in Shanghai in 2018, The Program for Professor of Special Appointment (Eastern Scholar) at Shanghai Institutions of Higher Learning and the 111 Project (B14018).

语种：英文

外文关键词：Cardiovascular system - Silica - Drug products - Fluorescence - Micelles - Hydrogen bonds - Nanosystems - Crosslinking - Targeted drug delivery - Controlled drug delivery

摘要：An ideal drug delivery system must have a high level of stability to ensure effective circulation and passive aggregation, good retention performance, and dynamic delivery and treatment monitoring. Thus, the development of a smart drug delivery carrier with both precise drug release and real-time detection remains a challenge. Herein, we propose a confined crosslink protocol to prepare an intelligent hybrid delivery system for auto-fluorescent monitoring, protonation-induced retention and precise drug release. The construction of this system involves the hydrolysis and condensation of (3-aminopropyl)triethoxysilane (APTES) silanes inside the Pluronic polymer micelles and thereafter a confined Schiff base crosslinking between glutaraldehyde (GA) and residual silane amino groups. The size of the intelligent docetaxel (DTX)-loaded nanosystem changes from similar to 25 nm in blood circulation or normal tissues (pH similar to 7.4) to similar to 250 nm in slightly acidic environments (pH similar to 6.5-7.0) owing to intra-molecular hydrogen bond-induced aggregation and imine cleavage-induced disintegration in the endosome (pH similar to 5.0-6.2) along with auto-fluorescent monitoring contributing to the high-efficiency chemotherapy. This work provides a new method to construct smart, acid-responsive and fluorescent-guided drug-delivery carrier systems for efficient and safe tumor chemotherapy.