文献类型：期刊文献

英文题名：Vicatia thibetica de Boiss Crude Polysaccharide Delay the Aging of the Heart and Kidneys

作者：Zhang, Daoxu[1,2];Wu, Chengyi[1];Ding, Zhiyang[3,4];Hong, Yunyu[1];Lu, Yehan[1];Zhou, Kunpeng[1];Deng, Ruixuan[1];Li, Laijia[1];Li, Chao[2];Yang, Yongcheng[5];Xia, Conglong[5];Li, Jian[1,6];Liu, Wenwen[3,4];An, Faliang[1];Hu, Zelan[1]

机构：[1]East China Univ Sci & Technol, State Key Lab Bioreactor Engn, Shanghai, Heilongjiang, Peoples R China;[2]Harbin Medisan Pharmaceut Co Ltd, Harbin, Heilongjiang, Peoples R China;[3]Hainan Univ, Key Lab Trop Biol Resources, Minist Educ, Haikou, Hainan, Peoples R China;[4]Hainan Univ, Hainan Engn Res Ctr Drug Screening & Evaluat, Haikou, Hainan, Peoples R China;[5]Dali Univ, Yunnan Int Joint Lab Dev Characterist Med & Food R, Dali, Yunnan, Peoples R China;[6]Shihezi Univ, Key Lab Xinjiang Phytomedicine Resource & Utilizat, Shihezi, Xinjiang, Peoples R China

年份：2026

外文期刊名：FOOD BIOENGINEERING

收录：WOS:【ESCI(收录号:WOS:001792325800001)】；

基金：We gratefully appreciate the financial support from the National Natural Science Foundation of China (grants 32121005 to J.L., 22577028 to Z.L.H., and 22437002 to J.L), Key Areas Science and Technology Research Project of XPCC (2025AB092).

语种：英文

外文关键词：cardiorenal aging; d-galactose induced aging; natural aging; Vicatia thibetica de Boiss

摘要：Vicatia thibetica de Boiss (V. thibetica) is a medicinal and edible plant traditionally used by the Bai ethnic community in Yunnan, China. Previous studies have reported that extracts derived from its roots have anti-aging effects, although the active components remain to be further investigated. Our preliminary findings revealed that the V. thibetica crude polysaccharide (VTCP) extends the lifespan of nematodes. In the present study, we systematically investigated the anti-aging effects of VTCP in both d-galactose-induced and naturally aged mouse models with particular emphasis on the heart and kidneys as primary organs of interest. The results demonstrated that VTCP significantly reduced the expression of senescent biomarkers and alleviated fibrosis levels in both the heart and kidney. In the d-galactose-induced aging model, VTCP exhibited potent antioxidant and anti-inflammatory capacities, effectively lowering oxidative stress markers and the senescence-associated secretory phenotypes (SASPs) in cardiorenal tissues. More importantly, in naturally aged mice, VTCP remarkably reshaped the gut microbiota composition, characterized by a significant enrichment of beneficial bacteria with the short-chain fatty acids producing potential and a suppression of inflammation-associated genera. Based on these findings, we propose that the core mechanism of VTCP likely involves targeted modulation of the gut microbiota to promote the production of beneficial metabolites, which subsequently suppresses systemic oxidative stress and inflammation, ultimately leading to synergistic protection of cardiorenal tissues. Collectively, our results highlight the promising potential of VTCP in counteracting cardiorenal aging and implicate the modulation of the gut-heart/kidney axis as an underlying mechanism.