文献类型：期刊文献

英文题名：Mild and Metal-Free Cross-Dehydrogenative Coupling of Nitrogen Heteroarenes with Aldehydes Enabled by Structural Hybridization of Promoting Reagents

作者：Zhao, Jianhong[2];Qian, Kun[3];Tong, Mengchao[1];Yuan, Qiyang[2];Zhang, Yongqiang[1]

机构：[1]East China Univ Sci & Technol, Sch Pharm, Shanghai Key Lab New Drug Design, Shanghai Frontiers Sci Ctr Optogenet Tech Cell Me, Shanghai 200237, Peoples R China;[2]East China Univ Sci & Technol, Sch Pharm, Lab Green Pharmaceut Proc & Technol, Shanghai 200237, Peoples R China;[3]Shanghai Pharmaceut Sch, Shanghai 200135, Peoples R China

年份：2022

卷号：7

期号：8

外文期刊名：CHEMISTRYSELECT

收录：;WOS:【SCI-EXPANDED(收录号:WOS:000760360800015)】；

基金：Financial support from the program of the National Natural Science Foundation of China (21871086, Y.-Q. Z.) is gratefully acknowledged.

语种：英文

外文关键词：cross-dehydrogenative coupling; nitrogen heteroarenes; aldehydes; structural hybridization; promoting reagents

摘要：A mild and metal-free cross-dehydrogenative coupling reaction of nitrogen heteroarenes with aldehydes has been developed by the structural hybridization of promoting reagents. The procedure is environmentally benign, cost-effective and industrially scalable, which allows the direct acylation of electron-deficient nitrogen heteroarenes in moderate to good yields. Furthermore, the synthetic utility of this new method in the synthesis of a variety of pharmaceutically relevant isoquinoline alkaloids has been also demonstrated.