文献类型：期刊文献

英文题名：Enantioselective aza-Morita-Baylis-Hillman reaction between acrylates and N-Boc isatin ketimines: asymmetric construction of chiral 3-substituted-3-aminooxindoles

作者：Zhao, Xuan;Li, Tian-Ze;Qian, Jing-Ying;Sha, Feng[1];Wu, Xin-Yan

机构：[1]E China Univ Sci & Technol, Key Lab Adv Mat, Shanghai 200237, Peoples R China; E China Univ Sci & Technol, Inst Fine Chem, Shanghai 200237, Peoples R China

年份：2014

卷号：12

期号：40

起止页码：8072

外文期刊名：ORGANIC & BIOMOLECULAR CHEMISTRY

收录：;EI(收录号：20144100083754);WOS:【SCI-EXPANDED(收录号:WOS:000342992400023)，CCR-EXPANDED(收录号:WOS:000342992400023)】；

基金：We are grateful for the financial support from the National Natural Science Foundation of China (21242007, 21102043) and the Fundamental Research Funds for the Central Universities.

语种：英文

外文关键词：Phosphorus compounds - Rate constants - Enantioselectivity

摘要：The first enantioselective aza-Morita-Baylis-Hillman reaction of acrylates with ketimines derived from isatins has been developed. With 2 mol% of chiral bifunctional phosphine-squaramide 4e, optically active 3-substituted-3-amino-2-oxindoles were obtained in excellent yields with up to 91% ee.