文献类型：期刊文献

英文题名：Heparin mimetics as potential intervention for COVID-19 and their bio-manufacturing

作者：Jiang, Lan[1,2];Zhang, Tianji[3];Lu, Hongzhong[4];Li, Saijuan[5];Lv, Kangjie[2];Tuffour, Alex[2];Zhang, Lixin[2];Ding, Kan[5];Li, Jin-Ping[6,7];Li, Hongmei[3];Liu, Xueting[2]

机构：[1]Nanjing Med Univ, Childrens Hosp, Dept Cardiothorac Surg, Nanjing 210093, Peoples R China;[2]East China Univ Sci & Technol, State Key Lab Bioreactor Engn, Shanghai 200237, Peoples R China;[3]Natl Inst Metrol, Div Chem & Analyt Sci, Key Lab Chem Metrol & Applicat Nutr & Hlth State M, Beijing 100029, Peoples R China;[4]Shanghai Jiao Tong Univ, Sch Life Sci & Biotechnol, State Key Lab Microbial Metab, Shanghai 200240, Peoples R China;[5]Shanghai Inst Mat Med, Chinese Acad Sci, Key Lab Receptor Res, Glycochemistry & Glycobiol Lab, Shanghai 201203, Peoples R China;[6]Beijing Univ Chem Technol, Int Res Ctr Soft Matter, Beijing 100029, Peoples R China;[7]Uppsala Univ, Dept Med Biochem & Microbiol, Uppsala, Sweden

年份：2023

卷号：8

期号：1

起止页码：11

外文期刊名：SYNTHETIC AND SYSTEMS BIOTECHNOLOGY

收录：;WOS:【SCI-EXPANDED(收录号:WOS:000889345500001)】；

基金：Acknowledgements We gratefully acknowledge the financial support from the National Key Research and Development Program of China (2021YFF0600700, 2020YFA090032 and 2019YFA0906201) , the Swedish research council (2020-05759) , and the National Natural Science Foundation of China (31720103901, 31961133004, 21907031, 21977029, 22108266) .

语种：英文

外文关键词：Heparin; Biosynthesis; Biological activities; Bio-production

摘要：The COVID-19 pandemic has caused severe health problems worldwide and unprecedented decimation of the global economy. Moreover, after more than 2 years, many populations are still under pressure of infection. Thus, a broader perspective in developing antiviral strategies is still of great importance. Inspired by the observed multiple benefits of heparin in the treatment of thrombosis, the potential of low molecular weight heparin (LMWH) for the treatment of COVID-19 have been explored. Clinical applications found that LMWH decreased the level of inflammatory cytokines in COVID-19 patients, accordingly reducing lethality. Furthermore, several in vitro studies have demonstrated the important roles of heparan sulfate in SARS-CoV-2 infection and the inhibitory effects of heparin and heparin mimetics in viral infection. These clinical observations and designed studies argue for the potential to develop heparin mimetics as anti-SARS-CoV-2 drug candidates. In this review, we summarize the properties of heparin as an anticoagulant and the pharmaceutical possibilities for the treatment of virus infection, focusing on the perspectives of developing heparin mimetics via chemical synthesis, chemoenzymatic synthesis, and bioengineered production by microbial cell factories. The ultimate goal is to pave the eminent need for exploring novel compounds to treat coronavirus infection-caused diseases.