文献类型：期刊文献

英文题名：Synthesis and Biological Evaluation of Nitromethylene Neonicotinoids Based on the Enhanced Conjugation

作者：Lu, Siyuan[1];Zhuang, Yingying[1];Wu, Ningbo[1];Feng, Yue[1];Cheng, Jiagao[1];Li, Zhong[1];Chen, Jie[2];Yuan, Jing[2];Xu, Xiaoyong[1]

机构：[1]E China Univ Sci & Technol, Inst Pesticides & Pharmaceut, Shanghai Key Lab Chem Biol, Shanghai 200237, Peoples R China;[2]Zhejiang Res Inst Chem Ind Ltd, Hangzhou 310023, Zhejiang, Peoples R China

年份：2013

卷号：61

期号：46

起止页码：10858

外文期刊名：JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY

收录：;EI(收录号：20134917047117);WOS:【SCI-EXPANDED(收录号:WOS:000327103400003)】；

基金：This work was financial supported by the National Basic Research Program of China (973 Program, 2010CB126100) and the National High Technology Research and Development Program of China (863 Program, 2011AA10A207). This work was also partly supported by the National Key Technology R&D Program of China (2011BAE06B01), the National Natural Science Foundation of China (21272071), Shanghai Leading Academic Discipline Project (Project B507), and the Fundamental Research Funds for the Central Universities and Special Fund for Agro-scientific Research in the Public Interest (201103007).

语种：英文

外文关键词：Neonicotinoids; conjugation; insecticidal activity

摘要：The neonicotinoids with a nitroconjugated system had excellent bioactivity, which could rival imidacloprid, and has been previously reported. However, the photodegradation and hydrolysis of this series of neonicotinoids was very quick according to our further investigation, which cannot be developed as a pesticide further. The approach to further enhance the conjugation was tried not only to increase the bioactivities but also to improve the stability in water and in the sun. A substituted phenyl group was introduced into the furan ring of compound 3. A total of 13 novel neonicotinoid analogues with a higher conjugation system were designed and synthesized. The target molecular structures have been confirmed on the basis of satisfactory analytical and spectral data. All compounds presented significant insecticidal activities on cowpea aphid (Aphis craccivora), cotton aphid (Aphis gossypii), and brown planthopper (Nilaparvata lugens). The stability test exhibited that the stability of novel analogues in water and under the mercury lamp has been improved significantly in comparison to compound 3.