文献类型：期刊文献

中文题名：Et_(3)N-Catalyzed Cycloaddition Reactions ofα-(Trifluoromethyl)styrenes with 2,2,2-Trifluorodiazoethane to Access Bis(trifluoromethyl)-Substituted Pyrazolines

作者：Chunmei Li[1];Xuxue Zhang[2];Jingjing He[1];Sixue Xu[1];Song Cao[1]

机构：[1]Shanghai Key Laboratory of Chemical Biology,School of Pharmacy,East China University of Science and Technology,Shanghai,200237 China;[2]College of Chemistry and Chemical Engineering,Qilu Normal University,Jinan,Shandong,250200 China

年份：2021

卷号：39

期号：2

起止页码：301

中文期刊名：Chinese Journal of Chemistry

外文期刊名：中国化学（英文版）

收录：CSTPCD;;Scopus;CSCD:【CSCD2021_2022】；

基金：support from the National Key Research and Development Program of China(No.2017YFD0200505)。

语种：英文

中文关键词：Cycloaddition;2,2,2-Trifluorodiazoethane;α-(Trifluoromethyl)styrenes;Pyrazoline;Et_(3)N-catalyzed

摘要：A novel and practical method for the synthesis of 3,5-bis(trifluoromethyl)-4,5-dihydro-1H-pyrazoles by [3+2] cycloaddition reactions of α-(trifluoromethyl)styrenes with 2,2,2-trifluorodiazoethane (CF3CHN2) has been developed. The cyclization reaction proceeds smoothly in the presence of a catalytic amount of Et_(3)N, affording a variety of bis(trifluoromethyl)-substituted 2-pyrazolines in good to excellent yields. This method also exhibits a broad substrate scope and tolerates various functional groups.