文献类型：期刊文献

英文题名：Metal-organic framework (MOF) hybridized gold nanoparticles as a bifunctional nanozyme for glucose sensing

作者：Tong, Pei-Hong[1,2];Wang, Jing-Jing[1,2];Hu, Xi-Le[1,2];James, Tony D.[4,5];He, Xiao-Peng[1,2,3]

机构：[1]East China Univ Sci & Technol, Key Lab Adv Mat, 130 Meilong Rd, Shanghai 200237, Peoples R China;[2]East China Univ Sci & Technol, Feringa Nobel Prize Scientist Joint Res Ctr, Sch Chem & Mol Engn, Joint Int Res Lab Precis Chem & Mol Engn, 130 Meilong Rd, Shanghai 200237, Peoples R China;[3]Eastern Hepatobiliary Surg Hosp, Natl Ctr Liver Canc, Int Cooperat Lab Signal Transduct, Shanghai 200438, Peoples R China;[4]Univ Bath, Dept Chem, Bath BA2 7AY, England;[5]Henan Normal Univ, Sch Chem & Chem Engn, Xinxiang 453007, Peoples R China

年份：2023

卷号：14

期号：28

起止页码：7762

外文期刊名：CHEMICAL SCIENCE

收录：;EI(收录号：20232914420678);WOS:【SCI-EXPANDED(收录号:WOS:001022298000001)】；

基金：The authors thank the Natural National Science Foundation of China (No. 92253306), the Fundamental Research Funds for the Central Universities (222201717003), the Programme of Introducing Talents of Discipline to Universities (B16017), and the Open Funding Project of the State Key Laboratory of Bioreactor Engineering. TDJ wishes to thank the Open Research Fund of the School of Chemistry and Chemical Engineering, Henan Normal University for support (2020ZD01). The Research Center of Analysis and Test of East China University of Science and Technology is gratefully acknowledged for assistance in analytical experiments.

语种：英文

外文关键词：Glucose - Glucose oxidase - Glucose sensors - Gold nanoparticles - Metal nanoparticles - Metal-Organic Frameworks

摘要：Inspired by natural enzymes that possess multiple catalytic activities, here we develop a bifunctional metal-organic frame-work (MOF) for biosensing applications. Ultrasmall gold nano-particles (AuNPs) are grown in the internal cavities of an iron (Fe) porphyrin-based MOF to produce a hybridized nanozyme, AuNPs@PCN-224(Fe), in which AuNPs and PCN-224(Fe) exhibit the catalytic activity of glucose oxidase (GOx) and horseradish peroxidase (HRP), respectively. We established that the bifunctional nanozyme was capable of a cascade reaction to generate hydrogen peroxide in the presence of d-glucose and oxygen in situ, and subsequently activate a colorimetric or chemiluminescent substrate through HRP-mimicking catalytic activity. The nanozyme was selective over a range of other saccharides, and 93% of the catalytic activity was retained after being recycled five times.