文献类型：期刊文献

英文题名：Nanostructured electrode based on multi-wall carbon nanotubes/Pt microparticles nanocomposite for electrochemical determination of thiols in rat striatum by high performance liquid chromatography separation

作者：Xian, Yuezhong[1,2]; Zhou, Yuyan[1]; Wang, Haiting[1]; Zhou, Lihui[3]; Liu, Fang[1]; Jin, Litong[1]

机构：[1]E China Normal Univ, Dept Chem, Shanghai 200062, Peoples R China;[2]Hunan Univ, State Key Lab Chemo Biosensing & Chemometr, Changsha 410082, Peoples R China;[3]E China Univ Sci & Technol, Ctr Anal & Res, Shanghai 2000237, Peoples R China

年份：2005

卷号：817

期号：2

起止页码：239

外文期刊名：JOURNAL OF CHROMATOGRAPHY B-ANALYTICAL TECHNOLOGIES IN THE BIOMEDICAL AND LIFE SCIENCES

收录：;EI(收录号：2005159034121);WOS:【SCI-EXPANDED(收录号:WOS:000226957700015)】；

语种：英文

外文关键词：multi-wall carbon nanotubes; Pt microparticles; L-cysteine; glutathione

摘要：In this paper, multi-wall carbon nanotubes (MWNTs)/Pt microparticles nanocomposite was prepared by electrodepositing Pt microparticles onto the MWNTs matrix. The surface of glassy carbon electrode was modified with this kind of nanocomposite for measurement of thiols, such as L-cysteine (L-Cys) and glutathione (GSH). Compared with the MWNTs or Pt microparticles modified electrode, the nanocomposite modified electrode exhibited high sensitivity and good stability for detection of thiols. According to the results of experiments, the peak currents of L-Cys and GSH are linear with their concentrations and the detection limits (S/N=3) are 2.9 x 10(-8) mol/L and 4.5 x 10(-8) mol/L, respectively. Coupled with microdialysis, the method has been successfully applied to the determination of these two thiols in rat striatal microdialysates. (C) 2004 Elsevier B.V. All rights reserved.