文献类型：期刊文献

英文题名：Preparation, characterization, and in vitro osteoblast functions of a nano-hydroxyapatite/polyetheretherketone biocomposite as orthopedic implant material

作者：Ma, Rui[1];Tang, Songchao[2,3];Tan, Honglue[1];Lin, Wentao[1];Wang, Yugang[1];Wei, Jie[2,3];Zhao, Liming[2,3];Tang, Tingting[1]

机构：[1]Shanghai Jiao Tong Univ, Sch Med, Shanghai Peoples Hosp 9, Shanghai Key Lab Orthoped Implants,Dept Orthoped, Shanghai 200011, Peoples R China;[2]E China Univ Sci & Technol, Key Lab Ultrafine Mat, Minist Educ, Shanghai 200237, Peoples R China;[3]E China Univ Sci & Technol, State Key Lab Bioreactor Engn, Shanghai 200237, Peoples R China

年份：2014

卷号：9

起止页码：3949

外文期刊名：INTERNATIONAL JOURNAL OF NANOMEDICINE

收录：;WOS:【SCI-EXPANDED(收录号:WOS:000340605900001)】；

基金：This research was financially supported by the National Natural Science Foundation of China (numbers 31271015, 81271705, and 51173041) and the Shanghai Science and Technology Development Fund (numbers 13DZ2294000, 13JC1403900, 12nm0500400, and 12441903600).

语种：英文

外文关键词：polyetheretherketone; nano-hydroxyapatite; biocomposite; osteoblast functions; orthopedic implant material

摘要：A bioactive composite was prepared by incorporating 40 wt% nano- hydroxyapatite (nHA) into polyetheretherketone (PEEK) through a process of compounding, injection, and molding. The mechanical and surface properties of the nHA/PEEK composite were characterized, and the in vitro osteoblast functions in the composite were investigated. The mechanical properties (elastic modulus and compressive strength) of the nHA/PEEK composite increased significantly, while the tensile strength decreased slightly as compared with PEEK. Further, the addition of nHA into PEEK increased the surface roughness and hydrophilicity of the nHA/PEEK composite. In cell tests, compared with PEEK and ultra-high-molecular-weight polyethylene, it was found that the nHA/PEEK composite could promote the functions of MC3T3-E1 cells, including cell attachment, spreading, proliferation, alkaline phosphatase activity, calcium nodule formation, and expression of osteogenic differentiation-related genes. Incorporation of nHA into PEEK greatly improved the bioperformance of PEEK. The nHA/PEEK composite might be a promising orthopedic implant material.