文献类型：期刊文献

英文题名：Current innovations in nutraceuticals and functional foods for intervention of non-alcoholic fatty liver disease

作者：Zhao, Mengyao[1,4];Chen, Shumin[1];Ji, Xiaoguo[1];Shen, Xin[1];You, Jiangshan[1];Liang, Xinyi[1];Yin, Hao[2];Zhao, Liming[1,3,4]

机构：[1]East China Univ Sci & Technol, R&D Ctr Separat & Extract Technol Fermentat Ind, Sch Biotechnol, State Key Lab Bioreactor Engn, Shanghai 200237, Peoples R China;[2]Shanghai Changzheng Hosp, Organ Transplant Ctr, Shanghai 200003, Peoples R China;[3]Shandong Univ Technol, Sch Life Sci, Zibo 255000, Shandong, Peoples R China;[4]Shanghai Collaborat Innovat Ctr Biomfg Technol SC, Shanghai 200237, Peoples R China

年份：2021

卷号：166

外文期刊名：PHARMACOLOGICAL RESEARCH

收录：;WOS:【SCI-EXPANDED(收录号:WOS:000643656100037)】；

基金：This work was financially supported by the National Key Research and Development Program of China (2019YFD0901805); China Postdoctoral Science Foundation (2019T120314); Shanghai Pujiang Program (18PJ1401900); the 111 Project (B18022); and the Fundamental Research Funds for the Central Universities (22221818014).

语种：英文

外文关键词：Functional food; Nutraceutical; Phytochemical; NAFLD; Gut microbiota

摘要：morbidity rates from non-alcoholic fatty liver disease (NAFLD), accompanied by elevated risk of lipid metabolism-related complications, has emerged as a growing problem worldwide. Treatment and prevention of NAFLD and chronic liver disease depends on the availability of safe, effective, and diverse therapeutic agents, the development of which is urgently needed. Supported by a growing body of evidence, considerable attention is now focused on interventional approaches that combines nutraceuticals and functional foods. In this review, we summarize the pathological progression of NAFLD and discuss the beneficial effects of nutraceuticals and the active ingredients in functional foods. We also describe the underlying mechanisms of these compounds in the intervention of NAFLD, including their effects on regulation of lipid homeostasis, activation of signaling pathways, and their role in gut microbial community dynamics and the gut-liver axis. In order to identify novel targets for treatment of lipid metabolism-related diseases, this work broadly explores the molecular mechanism linking nutraceuticals and functional foods, host physiology, and gut microbiota. Additionally, the limitations in existing knowledge and promising research areas for development of active interventions and treatments against NAFLD are discussed.