文献类型：期刊文献

英文题名：Catalyzing Generation and Stabilization of Oxygen Vacancies on CeO2-x Nanorods by Pt Nanoclusters as Nanozymes for Catalytic Therapy

作者：Zhang, Jiankang[1];Yang, Yu[2];Qin, Fengmin[1];Hu, Tingting[2];Zhao, Xinshuo[3];Zhao, Shichao[4];Cao, Yueqiang[5];Gao, Zhe[4];Zhou, Zhan[3];Liang, Ruizheng[2,7];Tan, Chaoliang[6];Qin, Yong[1,4]

机构：[1]Northwestern Polytech Univ, Interdisciplinary Res Ctr Biol & Catalysis, Sch Life Sci, Xian 710072, Peoples R China;[2]Beijing Univ Chem Technol, Beijing Adv Innovat Ctr Soft Matter Sci & Engn, State Key Lab Chem Resource Engn, Beijing 100029, Peoples R China;[3]LuoYang Normal Univ, Coll Chem & Chem Engn, Henan Key Lab Funct Oriented Porous Mat, Luoyang 471934, Henan, Peoples R China;[4]Chinese Acad Sci, State Key Lab Coal Convers, Inst Coal Chem, Taiyuan 030001, Peoples R China;[5]East China Univ Sci & Technol, Sch Chem Engn, State Key Lab Chem Engn, Shanghai 200237, Peoples R China;[6]Univ Hong Kong, Dept Elect & Elect Engn, Pokfulam Rd, Hong Kong 999077, Peoples R China;[7]Quzhou Inst Innovat Resource Chem Engn, Quzhou 324000, Peoples R China

年份：2023

卷号：12

期号：31

外文期刊名：ADVANCED HEALTHCARE MATERIALS

收录：;EI(收录号：20233914773631);WOS:【SCI-EXPANDED(收录号:WOS:001070296200001)】；

基金：J.Z., Y.Y., and F.Q. contributed equally to this work. All animal experiments were permitted by the Animal Care and Use Committee of China-Japan Friendship Hospital. All study procedures were performed in accordance with the protocols approved by the Animal Research Center of China-Japan Friendship Hospital. The authors appreciate the financial support from the National Natural Science Foundation of China (22102131, U1910209), National Science Fund for Distinguished Young Scholars (21825204), Fundamental Research Funds for the Central Universities (G2023KY0605), and Natural Science Basic Research Plan in Shaanxi Province of China (2021JQ-090). Z.Z. thanks the funding support from National Natural Science Foundation of China (52102348) and the Science and Technology Innovation Talent Program of University in Henan Province (23HASTIT016).~C.T. thanks the funding support from the National Natural Science Foundation of China-Excellent Young Scientists Fund (Hong Kong and Macau) (52122002). R.L. thanks the funding support from National Natural Science Foundation of China (22288102, 21971007) and the Beijing Natural Science Foundation (2212044). The authors would like to thank the Analytical & Testing Center of Northwestern Polytechnical University for HAADF-STEM measurements and Shanghai Synchrotron Radiation Facility for XAFS measurements. Dr. Fangxian Cao is acknowledged for guiding the synthesis of porous CeO2 NRs.

语种：英文

外文关键词：catalytic therapy; CeO2 nanomaterials; nanozymes; oxygen vacancies; Pt nanoclusters

摘要：Although CeO2 nanomaterials have been widely explored as nanozymes for catalytic therapy, they still suffer from relatively low activities. Herein, the catalyzing generation and stabilization of oxygen vacancies on CeO2 nanorods by Pt nanoclusters via H-2 gas reduction under mild temperature (350 degrees C) to obtain Pt/CeO2-x, which can serve as a highly efficient nanozyme for catalytic cancer therapy, is reported. The deposited Pt on CeO2 by the atomic layer deposition technique not only can serve as the catalyst to generate oxygen vacancies under mild temperature reduction through the hydrogen spillover effect, but also can stabilize the generated oxygen vacancies. Meanwhile, the oxygen vacancies also provide anchoring sites for Pt forming strong metal-support interactions and thus preventing their agglomerations. Importantly, the Pt/CeO2-x reduced at 350 degrees C (Pt/CeO2-x-350R) exhibits excellent enzyme-mimicking catalytic activity for generation of reactive oxygen species (e.g., .OH) as compared to other control samples, including CeO2, Pt/CeO2, and Pt/CeO2-x reduced at other temperatures, thus achieving excellent performance for tumor-specific catalytic therapy to efficiently eliminate cancer cells in vitro and ablate tumors in vivo. The excellent enzyme-mimicking catalytic activity of Pt/CeO2-x-350R originates from the good catalytic activities of oxygen vacancy-rich CeO2-x and Pt nanoclusters.