文献类型：期刊文献

英文题名：A straightforward preparation of fluorine-containing 1,2-dihydropyrimidines and pyrimidines with 2,2-dihydropolyfluoroalkylaldehydes

作者：Yang, Xian-Jin[1,2];Zhang, Li-Si[2];Liu, Jin-Tao[1]

机构：[1]Chinese Acad Sci, Shanghai Inst Organ Chem, Key Lab Organofluorine Chem, Shanghai 200032, Peoples R China;[2]E China Univ Sci & Technol, Inst Fine Chem, Adv Mat Lab, Shanghai 200237, Peoples R China

年份：2007

卷号：63

期号：25

起止页码：5643

外文期刊名：TETRAHEDRON

收录：;WOS:【SCI-EXPANDED(收录号:WOS:000252076300032)】；

语种：英文

外文关键词：2,2-dihydropolyfluoroalkylaldehyde; fluorine-containing 1,2-dihydropyrimidine; fluorine-containing pyrimidine; ammonia; zinc chloride

摘要：The reactions of 2,2-dihydropolyfluoroalkylaldehydes with ammonia and enol ethers or carbonyl compounds are described. In the presence of zinc chloride, all reactions took place readily in THF at 50 degrees C to give fluorine-containing 1,2-dihydropyrimidines in moderate to good yields. Dehydrogenation of the resulting fluorine-containing 1,2-dihydropyrimidines with tetrachloro-1,4-benzoquinone (TCBQ) or 2,3-dichloro-5,6-dicyano-1,4-benzoquinone (DDQ) at room temperature afforded the corresponding fluorine-containing pyrimidines in good yields. (C) 2007 Elsevier Ltd. All rights reserved.