文献类型：期刊文献

英文题名：A novel antibiotic: the antimicrobial effects of CFBSA and its application on electronspun wound dressing

作者：Sun, Shu[1];Cao, Lei[2];Wu, Jinglei[1];Sun, Binbin[1];El-Newehy, Mohamed[3];Abdulhameed, Meera Moydeen[3];Mo, Xiumei[1];Yang, Xianjin[4,5];Zheng, Hao[1]

机构：[1]Donghua Univ, Coll Biol Sci & Med Engn, Shanghai Engn Res Ctr Nanobiomat & Regenerat Med, Shanghai 201620, Peoples R China;[2]Shanghai Jiao Tong Univ, Shanghai Gen Hosp, Trauma Ctr, Sch Med,Orthopaed Traumatol, Shanghai 201620, Peoples R China;[3]King Saud Univ, Coll Sci, Dept Chem, POB 2455, Riyadh 11451, Saudi Arabia;[4]East China Univ Sci & Technol, Key Lab Adv Mat, Shanghai 200231, Peoples R China;[5]East China Univ Sci & Technol, Inst Fine Chem, Shanghai 200231, Peoples R China

年份：2024

卷号：19

期号：5

外文期刊名：BIOMEDICAL MATERIALS

收录：;EI(收录号：20242816692733);WOS:【SCI-EXPANDED(收录号:WOS:001264294100001)】；

基金：This work was supported by the Fundamental Research Funds for the Central Universities (No.2232023D-10). This project was also supported by Researchers Supporting Project Number (RSP2024R65), King Saud University, Riyadh, Saudi Arabia.

语种：英文

外文关键词：nitrogen-fluoride compounds; electrospinning; antimicrobial; antimicrobial mechanism; wound dressing

摘要：N-chloro-N-fluorobenzenesulfonylamide (CFBSA), was a novel chlorinating reagent, which exhibits potential antibacterial activities. In this study, CFBSA was confirmed as a wide-broad antimicrobial and bactericidal drug against different gram-negative bacteria, gram-positive bacteria and fungi, while it was found to have low cytotoxicity for eukaryotic cells. In addition, microorganism morphology assay and oxidative stress test was used to determine the antimicrobial mechanisms of CFBSA. According to the results, CFBSA probably had a target on cell membrane and killed microorganism by disrupting its cell membrane. Then, CFBSA was first combined with poly(L-lactide-co-caprolactone) (PLCL)/SF via electrospinning and applied in wound dressings. The characterization of different PLCL/SF of CFBSA-loaded nanofibrous mats was investigated by SEM, water contact angle, Fourier transform infrared spectroscopy, cell compatibility and antimicrobial test. CFBSA-loaded PLCL/SF nanofibrous mats showed excellent antimicrobial activities. In order to balance of the biocompatibility and antibacterial efficiency, SP-2.5 was selected as the ideal loading concentration for further application of CFBSA-loaded PLCL/SF. In conclusion, the electrospun CFBSA-loaded PLCL/SF nanofibrous mat with its broad-spectrum antimicrobial and bactericidal activity and good biocompatibility showed enormous potential for wound dressing.