文献类型：期刊文献

英文题名：Dual-Responsive Fluorescent Probes: Advances in Biosensing, Diagnosis and Therapy

作者：Liu, Jihong[1,2];Wu, Luling[3];Zhu, Zhirong[1,2];Yan, Chenxu[1,2];Zhang, Yutao[1,2];Yang, Ting[1,2];Xu, Shiyun[1,2];Yang, Haojian[1,2];Liu, Shichang[1,2];Tang, Wenjun[1,2];Ma, Xiaoyu[1,2];Lewis, Simon E.[3];Wang, Qi[1,2,4];James, Tony D.[3,5];Zhu, Wei-Hong[1,2,4]

机构：[1]East China Univ Sci & Technol, Sch Chem & Mol Engn, Inst Fine Chem,Shanghai Key Lab Funct Mat Chem,Key, Frontiers Sci Ctr Materiobiol & Dynam Chem,Feringa, Shanghai 200237, Peoples R China;[2]East China Univ Sci & Technol, Sch Chem & Mol Engn, Inst Fin Chem,Shanghai Key Lab Funct Mat Chem,Join, Frontiers Sci Ctr Materiobiol & Dynam Chem,Feringa, Shanghai 200237, Peoples R China;[3]Univ Bath, Dept Chem, Bath BA2 7AY, England;[4]East China Univ Sci & Technol, Ctr Photosensit Chem Engn, Shanghai 200237, Peoples R China;[5]Henan Normal Univ, Sch Chem & Chem Engn, Xinxiang 453007, Peoples R China

年份：2026

卷号：36

期号：5

外文期刊名：ADVANCED FUNCTIONAL MATERIALS

收录：;EI(收录号：20253218946902);WOS:【SCI-EXPANDED(收录号:WOS:001546162300001)】；

基金：J.L. and L.W. contributed equally to this work. This work was supported by the National Key Research and Development Program of China (2021YFA0910000), National Natural Science Foundation of China Excellent Young Scientist Scheme (22222803), National Natural Science Foundation of China (22404056), Science and Technology Commission of Shanghai Municipality (grant No.24DX1400200), Fellowship of China National Postdoctoral Program for Innovative Talents (BX20240114), Shanghai Post-doctoral Excellence Program (2024776) and China Postdoctoral Science Foundation (2025M771000). T.D.J. wishes to thank the University of Bath and the Open Research Fund of the School of Chemistry and Chemical Engineering, Henan Normal University (2020ZD01) for support. Scheme created using Biorender.com.

语种：英文

外文关键词：biosensing; diagnosis; dual-responsive; fluorescent probes; therapy

摘要：Recent years have witnessed rapid developments in molecular imaging for fundamental biomedical research and clinical diagnostics. Particularly, fluorescence imaging represents an indispensable technique, enabling longitudinal monitoring of intravital physiopathological activities in a real-time and non-invasive manner. Dual-responsive fluorescent probes, which circumvent non-specific signal activation and background noise, have exhibited remarkably enhanced selectivity, high spatiotemporal resolution, and multiplexing capability. With the increasing prevalence of precision medicine, dual-responsive fluorescent probes offer promising opportunities to enhance diagnostic accuracy and optimize therapeutic efficacy. In this review, the design strategies for customized dual-responsive fluorescent probes are comprehensively summarized. Subsequently, representative examples in biosensing, diagnosis, and therapy are highlighted. Finally, the review provides perspectives and discusses key challenges in advancing dual-responsive fluorescent probes toward clinical biomedical applications.