文献类型：期刊文献

英文题名：The effects of size and surface functionalization of polystyrene nanoplastics on stratum corneum model membranes: An experimental and computational study

作者：Cheng, Shiqiang[1];Hu, Jiajie[2];Guo, Chen[1];Ye, Zhicheng[1];Shang, Yazhuo[1];Lian, Cheng[1];Liu, Honglai[1]

机构：[1]East China Univ Sci & Technol, Sch Chem & Mol Engn, Key Lab Adv Mat, Shanghai 200237, Peoples R China;[2]Zhejiang Xianju Pharmaceut Co Ltd, Taizhou 318000, Peoples R China

年份：2023

卷号：638

起止页码：778

外文期刊名：JOURNAL OF COLLOID AND INTERFACE SCIENCE

收录：;EI(收录号：20230813601311);WOS:【SCI-EXPANDED(收录号:WOS:000944366700001)】；

基金：We acknowledge the financial support of this work by the National Natural Science Foundation of China for Innovative Research Groups (No. 51621002) .

语种：英文

外文关键词：Stratum corneum; Nanoplastics; Particle size; Surface functionalization; Molecular dynamics; Cytotoxicity

摘要：Nanoplastics are mainly generated from the decomposition of plastic waste and artificial production and have attracted much attention due to their wide distribution in the environment and the potential risk for humans. As the largest organ of the human body, the skin is inevitably in contact with nanoplastics. Stratum corneum is the first barrier when the skin is exposed to nanoplastics. However, little is known about the interactions between nanoplastics and stratum corneum. Here, the effects of particle size and surface functionalization (amino-modified and carboxy-modified) of polystyrene nanoplastics on the stratum corneum models were studied by Langmuir monolayer and molecular dynamics simulations. An equimolar mixture of ceramide/cholesterol/free fatty acid was used to mimic stratum corneum inter-cellular lipids. The Langmuir monolayer studies demonstrated that the larger size and surface function-alization of polystyrene nanoplastics significantly reduced the stability of stratum corneum lipid monolayer in a concentration-dependent fashion. Simulation results elucidated that functionalized poly-styrene oligomers had a stronger interaction with lipid components of the stratum corneum model mem-brane. The cell experiments also indicated that functionalized polystyrene nanoplastics, especially for amino-modified polystyrene nanoplastics, had significant cytotoxicity on normal human dermal fibrob-last cells. Our results provide fundamental information and the basis for a deeper understanding of the health risks of nanoplastics to humans.(c) 2023 Elsevier Inc. All rights reserved.