文献类型：期刊文献

英文题名：Improvement of rBMSCs Responses to Poly(propylene carbonate) Based Biomaterial through Incorporation of Nanolaponite and Surface Treatment Using Sodium Hydroxide

作者：Liu, Jingyuan[1];Shen, Xuening[1];Tang, Songchao[1];Li, Hong[2];Mei, Shiqi[1];Zheng, Han[1];Sun, Yupeng[1];Zhao, Jun[3];Kaewmanee, Rames[1];Yang, Lili[4];Gan, Qi[1];Wei, Jie[1]

机构：[1]East China Univ Sci & Technol, Key Lab Ultrafine Mat, Minist Educ, 130 Meilong Rd, Shanghai 200237, Peoples R China;[2]Sichuan Univ, Coll Phys Sci & Technol, 17 South Renmin Rd, Chengdu 610041, Peoples R China;[3]Shanghai Jiao Tong Univ, Shanghai Key Lab Stomatol, Shanghai Peoples Hosp 9, 639 Mfg Bur Rd, Shanghai 200011, Peoples R China;[4]Second Mil Med Univ, Dept Orthopaed Surg, Changzheng Hosp, 415 Fengyang Rd, Shanghai 200003, Peoples R China

年份：2020

卷号：6

期号：1

起止页码：329

外文期刊名：ACS BIOMATERIALS SCIENCE & ENGINEERING

收录：;EI(收录号：20200208019660);WOS:【SCI-EXPANDED(收录号:WOS:000507429200029)】；

基金：Financial support was from the National Natural Science Foundation of China (Grants 81572194, 81771990, and 51772194) and Key Medical Program of Science and Technology Development of Shanghai (Grants 17441900600 and 17441902000).

语种：英文

外文关键词：poly(propylene carbonate); laponite; nanocomposite; NaOH treatment; bone repair

摘要：Poly(propylene carbonate) (PPC) has aroused extensive attention in the biomaterial field because of its excellent biocompatibility and appropriate degradability, but surface hydrophobicity and bioinertness limit its applications for bone repair and tissue engineering. In this study, a bioactive PPC/laponite (LAP) nanocomposite (PL) was prepared by a melt-blending method, and a microporous surface on PPC and PL (PT and PLT) was created by sodium hydroxide (NaOH) treatment. The results demonstrated that the surface roughness, hydrophilicity, surface energy, and degradability as well as protein adsorption of PLT were obviously improved compared with PPC. Moreover, the degradability of PLT was remarkably enhanced with a slight increase of pH values in Tris-HCl solution. Furthermore, adhesion and proliferation as well as osteogenic differentiation of rat bone marrow mesenchymal stem cells (rBMSCs) to PLT were significantly promoted compared with PPC. The results suggested that incorporating LAP into PPC obviously improved the surface performance of PL (with nanotopography), and surface treatment with NaOH further enhanced surface properties of PLT (with micronanotopography and hydrophilic groups), which significantly promoted responses of rBMSCs. In short, PLT displayed excellent cytocompatibility, which would have great potential for bone regeneration.