文献类型：期刊文献

英文题名：A new abyssomicin polyketide with anti-influenza A virus activity from a marine-derived Verrucosispora sp. MS100137

作者：Zhang, Jingyu[1];Li, Bixiao[1,2,3];Qin, Yujie[3];Karthik, Loganathan[1,4];Zhu, Guoliang[1];Hou, Chengjian[1];Jiang, Lan[1];Liu, Miaomiao[5];Ye, Xin[3];Liu, Mei[3];Hsiang, Tom[6];Dai, Huanqin[3];Zhang, Lixin[1];Liu, Xueting[1]

机构：[1]East China Univ Sci & Technol, State Key Lab Bioreactor Engn, Shanghai 200237, Peoples R China;[2]Anhui Univ, Inst Phys Sci & Informat Technol, Hefei 230601, Anhui, Peoples R China;[3]Chinese Acad Sci, Inst Microbiol, Key Lab Pathogen Microbiol & Immunol, Beijing 100101, Peoples R China;[4]Sri Shakthi Inst Engn & Technol Autonomous, Coimbatore, Tamil Nadu, India;[5]Griffith Univ, Griffith Inst Drug Discovery, Brisbane, Qld 4111, Australia;[6]Univ Guelph, Sch Environm Sci, Guelph, ON N1G 2W1, Canada

年份：2020

卷号：104

期号：4

起止页码：1533

外文期刊名：APPLIED MICROBIOLOGY AND BIOTECHNOLOGY

收录：;EI(收录号：20200107978564);WOS:【SCI-EXPANDED(收录号:WOS:000519153800012)】；

语种：英文

外文关键词：Abyssomicin; Proximicin; Marine-derived Verrucosispora sp; OSMAC; Anti-influenza A virus

摘要：Marine microorganisms live in dramatically different environments and have attracted much attention for their structurally unique natural products with potential strong biological activity. Based on the one strain-many compounds (OSMAC) strategy and liquid chromatography mass spectrometry (LC-MS) methods, our continuing efforts on the investigation of novel active compounds from marine Verrucosispora sp. MS100137 has led to the identification of a new polycyclic metabolite, abyssomicin Y (1), together with six known abyssomicin and proximicin analogs (2-7). Abyssomicin Y is a type I abyssomicin with an epoxide group at C-8 and C-9. Compounds 1-3 showed potent inhibitory effects against the influenza A virus; their observed inhibition rates were 97.9%, 98.3%, and 95.9%, respectively, at a concentration of 10 mu M, and they displayed lower cytotoxicity than 4. The structures were determined by different NMR techniques and HRMS experiments. This investigation revealed that OSMAC could serve as a useful method for enabling the activation of the silent genes in the microorganism and for the formation of previously unreported active secondary metabolites.