文献类型：期刊文献

英文题名：'One-pot' synthesis of 4-substituted 1,5-diaryl-1H-pyrazole-3-carboxylates via lithium tert-butoxide-mediated sterically hindered Claisen condensation and Knorr reaction

作者：Jiang, Jian-An[1];Huang, Wei-Bin[1];Zhai, Jiao-Jiao[1];Liu, Hong-Wei[1];Cai, Qi[1];Xu, Liu-Xin[1];Wang, Wei[1,2];Ji, Ya-Fei[1]

机构：[1]E China Univ Sci & Technol, Sch Pharm, Shanghai 200237, Peoples R China;[2]Univ New Mexico, Dept Chem & Chem Biol, Albuquerque, NM 87131 USA

年份：2013

卷号：69

期号：2

起止页码：627

外文期刊名：TETRAHEDRON

收录：;WOS:【SCI-EXPANDED(收录号:WOS:000314371800028)，CCR-EXPANDED(收录号:WOS:000314371800028)】；

基金：We gratefully acknowledge the National Natural Science Foundation of China (Project No. 21176074) for financial support.

语种：英文

外文关键词：Lithium tert-butoxide; Sterically hindered Claisen condensation; 3-Substituted 4-aryl-2,4-diketoesters; Knorr reaction; 4-Substituted 1,5-diaryl-1H-pyrazole-3-carboxylates

摘要：concise 'one-pot' synthesis of a variety of 4-substituted 1,5-diaryl-1H-pyrazole-3-carboxylates has been developed in moderate to good yields with excellent regioselectivity. Less cost lithium tert-butoxide has been identified as a base for sterically hindered Claisen condensation to efficiently generate the labile 3-substituted 4-aryl-2,4-diketoesters. Furthermore, extensive studies lead to a 'one-pot' process by combination of the Claisen condensation and the Knorr reaction for the synthesis of highly valuable 4-substituted 1,5-diaryl-1H-pyrazole-3-carboxylates. (c) 2012 Elsevier Ltd. All rights reserved.