文献类型：期刊文献

英文题名：A supramolecular photosensitizer for combating multiple antibiotic resistance via photodynamic biofilm dispersion

作者：Chen, Suwen[1];Xie, Jun[1];Weng, Sihao[1];Meng, Wangyang[2,3];Zheng, Jiahao[1];Huang, Baoxuan[1];Zhan, Rumeng[1];Zhang, Weian[1];Tian, Jia[1]

机构：[1]East China Univ Sci & Technol, Sch Chem & Mol Engn, Shanghai Key Lab Funct Mat Chem, 130 Meilong Rd, Shanghai 200237, Peoples R China;[2]Shanghai Jiao Tong Univ, Ruijin Hosp, Sch Med, Dept Thorac Surg, 197 Ruijin Rd Two, Shanghai 200025, Peoples R China;[3]Shanghai Jiao Tong Univ, Sch Med, Shanghai Inst Immunol, 280 Chongqing South Rd, Shanghai 200025, Peoples R China

年份：2024

卷号：496

外文期刊名：CHEMICAL ENGINEERING JOURNAL

收录：;EI(收录号：20243016750762);WOS:【SCI-EXPANDED(收录号:WOS:001278964300001)】；

基金：This study was financially supported by the National Natural Science Foundation of China (No. 52333014, 22075079 and 52203009) . All animal experimental procedures were carried out in accordance with Chinese legislation on the Use and Care of Research Animals, and institutional guidelines for the Care and Use of laboratory animals established by the East China University of Science and Technology Animal Studies Committee.

语种：英文

外文关键词：Porphyrin; Photodynamic therapy; Ciprofloxacin; Host-guest interaction; Immune response

摘要：Antibiotic resistance and biofilm formation have represented a major public health concern to the treatment of infectious diseases. Photodynamic therapy can not only generate toxic reactive oxygen species (ROS) to kill bacteria but also stimulate the immune response, which is less likely to induce bacterial resistance and represented as an effective antibacterial treatment. In this study, we presented a porphyrin (TPP) /ciprofloxacin (CIP) based supramolecular photosensitizer nanoparticles (TPP-CIP NPs) which could generate ROS, cascade release antibiotics, and trigger immune response for antibacterial, biofilm dispersion and wound healing via photodynamic-immunotherapy and enhanced antibiotic penetration. Upon light irradiation, the porphyrins in the system generated ROS and cleaved the thioketal linkers, releasing ciprofloxacin for killing antibiotic-sensitive bacteria that have developed because of the destruction of their external structure by ROS. Furthermore, the ROS simultaneously activated effective immune responses including the activation of dendritic cells and T cells. In vitro studies illustrated that the supramolecular nanoparticles exhibited effective antibacterial performance against both Gram-positive and Gram-negative bacteria, and biofilm dispersion capacity. In vivo studies confirmed TPP-CIP NPs possessed effective antibacterial effect and wound healing against methicillin resistant staphylococcus aureus infection. This research provides a promising synergistic strategy for combating multi-drug resistant bacterial infections.