文献类型：期刊文献

英文题名：Palladium-Catalyzed β-C(sp3)-H Arylation of Aliphatic Ketones Enabled by a Transient Directing Group

作者：Wang, Yangyang[1,2];Wu, Gaorong[1,2];Xu, Xiaobo[1,2];Pang, Binghan[1,2];Liao, Shaowen[3];Ji, Yafei[1,2]

机构：[1]East China Univ Sci & Technol, Engn Res Ctr Pharmaceut Proc Chem, Minist Educ, Shanghai 200237, Peoples R China;[2]East China Univ Sci & Technol, Sch Pharm, Shanghai 200237, Peoples R China;[3]Shanghai Jinli Pharmaceut Co Ltd, Shanghai 201507, Peoples R China

年份：2021

卷号：86

期号：10

起止页码：7296

外文期刊名：JOURNAL OF ORGANIC CHEMISTRY

收录：;EI(收录号：20212210416448);WOS:【SCI-EXPANDED(收录号:WOS:000656056500026)，CCR-EXPANDED(收录号:WOS:000656056500026)】；

基金：We gratefully thank the National Natural Science Foundation of China (Project No. 21676088) for financial support.

语种：英文

外文关键词：Aromatic compounds - Catalysis - Palladium

摘要：The direct arylation of aliphatic ketones has been developed via Pd-catalyzed beta-C(sp(3))-H bond functionalization with 2-(aminooxy)-N,N-dimethylacetamide as a novel transient directing group (TDG), which showed remarkable directing ability to generate arylated products in moderate to good yields. Furthermore, the reaction can tolerate abundant substrate of ketones and aryl iodides. This study expands the scope of applications for TDGs.