文献类型：期刊文献

英文题名：Cytotoxic Anthranilic Acid Derivatives from Deep Sea Sediment-Derived Fungus Penicillium paneum SD-44

作者：Li, Chun-Shun[1];Li, Xiao-Ming[1];Gao, Shu-Shan[1];Lu, Yan-Hua[2];Wang, Bin-Gui[1]

机构：[1]Chinese Acad Sci, Inst Oceanol, Key Lab Expt Marine Biol, Qingdao 266071, Peoples R China;[2]E China Univ Sci & Technol, State Key Lab Bioreactor Engn, Shanghai 200237, Peoples R China

年份：2013

卷号：11

期号：8

起止页码：3068

外文期刊名：MARINE DRUGS

收录：;WOS:【SCI-EXPANDED(收录号:WOS:000330521300024)】；

基金：This work was financially supported by grants from National Natural Science Foundation of China (30901880) and from the Ministry of Science and Technology of China (2012AA092104 and 2013AA092901).

语种：英文

外文关键词：marine fungus; sediment; anthranilic acid; Penicillium paneum; cytotoxicity

摘要：Five new anthranilic acid derivatives, penipacids A-E (1-5), together with one known analogue (6), which was previously synthesized, were characterized from the ethyl acetate extract of the marine sediment-derived fungus Penicillium paneum SD-44. Their structures were elucidated mainly by extensive NMR spectroscopic and mass spectrometric analysis. The cytotoxicity and antimicrobial activity of the isolated compounds were evaluated. Compounds 1, and 5 exhibited inhibitory activity against human colon cancer RKO cell line, while compound 6 displayed cytotoxic activity against Hela cell line.