文献类型：期刊文献

英文题名：Copper-catalyzed enantioselective Mannich reaction between N-acylpyrazoles and isatin-derived ketimines

作者：Lu, Jian[1,2];Fan, Ying[1,2];Sha, Feng[1,2];Li, Qiong[1,2];Wu, Xin-Yan[1,2]

机构：[1]East China Univ Sci & Technol, Sch Chem & Mol Engn, Key Lab Adv Mat, Shanghai 200237, Peoples R China;[2]East China Univ Sci & Technol, Sch Chem & Mol Engn, Inst Fine Chem, Shanghai 200237, Peoples R China

年份：2019

卷号：6

期号：15

起止页码：2687

外文期刊名：ORGANIC CHEMISTRY FRONTIERS

收录：;EI(收录号：20193007234137);WOS:【SCI-EXPANDED(收录号:WOS:000476771100014)】；

基金：We are grateful for the financial support by Shanghai Pujiang Program (18PJD010) and the Fundamental Research Funds for the Central Universities (222201814019).

语种：英文

外文关键词：Enantioselectivity - Copper

摘要：A copper-catalyzed enantioselective Mannich reaction between N-acylpyrazoles and isatin-derived ketimines is developed. With 5 mol% Cu(CH3CN)(4)PF6 complexed with 6 mol% chiral amidophosphine ligand L8, 3-substituted 3-amino-2-oxindoles with contiguous stereocenters were produced in 92-99% yields with excellent diastereoselectivities (97 : 3 to 99 : 1 dr) and 94-99% ee under mild conditions.